Synthetic Route of C22H43NO《Different metabolites induced by deoxynivalenol in the serum and urine of weaned rabbits detected using LC-MS-based metabolomics》 was published in 2021. The authors were Li, Fuchang;Huang, Libo;Liu, Quancheng;Wang, Pengwei;Chen, Hongju;Wang, Chunyang, and the article was included in《Comparative Biochemistry and Physiology, Part C: Toxicology & Pharmacology》. The author mentioned the following in the article:
The main toxic effects of deoxynivalenol (DON) are the result of long-term accumulation, and there are no obvious clin. signs at the early stage. Specific metabolites in blood and urine can be used as biomarkers and become an important diagnostic indicator for DON poisoning monitoring. This study aimed to reveal the differences in DON-induced metabolites in the serum and urine of weaned rabbits. Thirty-two weaned rabbits were divided into two groups: control group and DON group. Both groups of rabbits were fed a basic diet. Rabbits in the DON group were administered 1.5 mg/kg b.w. DON by i.p. injection on an empty stomach in the morning every two days. Rabbits in the control group were injected with the same amount of saline every two days in the same way. After the 25-day trial, serum and urine samples from different exptl. periods were collected. The results based on the LC-MS/MS method showed that DON can be metabolized rapidly in blood, and urine is the main metabolic pathway for DON. Data based on metabolomics illustrated that underlying biomarkers in serum were mainly involved in glycerophospholipid metabolism, tryptophan metabolism and pentose and glucuronate interconversions, while those in urine samples were involved in caffeine metabolism, glycine, serine and threonine metabolism, and terpenoid backbone biosynthesis. Correlation anal. suggested that DON can induce changes in certain disease-related metabolites in serum and urine. In conclusion, the pathogenic mechanism of DON includes multiple levels, indicating that DON poisoning is caused by multiple factors acting on multiple links.cis-13-Docosenamide (cas: 112-84-5) were involved in the experimental procedure.
cis-13-Docosenoamide(cas: 112-84-5) is a primary fatty amide resulting from the formal condensation of the carboxy group of erucic acid with ammonia.Synthetic Route of C22H43NO It is commonly used as a slip additive in the plastic manufacturing industry.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics