Cheng, Xingkai;Man, Xuejing;Wang, Zitong;Liang, Li;Zhang, Fan;Wang, Zhiwen;Liu, Pengfei;Lei, Bin;Hao, Jianjun;Liu, Xili published 《Fungicide SYP-14288 inducing multidrug resistance in Rhizoctonia solani》 in 2020. The article was appeared in 《Plant Disease》. They have made some progress in their research.Application In Synthesis of N,2-Dihydroxybenzamide The article mentions the following:
Rhizoctonia solani is a widely distributed soilborne plant pathogen, and can cause significant economic losses to crop production In chem. controls, SYP-14288 is highly effective against plant pathogens, including R. solani. To examine the sensitivity to SYP-14288, 112 R. solani isolates were collected from infected rice plants. An established baseline sensitivity showed that values of effective concentration for 50% growth inhibition (EC50) ranged from 0.0003 to 0.0138μg/mL, with an average of 0.0055 ± 0.0030μg/mL. The frequency distribution of the EC50 was unimodal and the range of variation factor (the ratio of maximal over minimal EC50) was 46.03, indicating that all wild-type strains were sensitive to SYP-14288. To examine the risk of fungicide resistance, 20 SYP-14288-resistant mutants were generated on agar plates amended with SYP-14288. Eighteen mutants remained resistant after 10 transfers, and their fitness was significantly different from the parental strain. All of the mutants grew more slowly but showed high virulence to rice plants, though lower than the parental strain. A crossresistance assay demonstrated that there was a pos. correlation between SYP-14288 and fungicides having or not having the same mode of action with SYP-14288, including fluazinam, fentin chloride, fludioxonil, difenoconazole, cyazofamid, chlorothalonil, and 2,4-dinitrophen. This result showed a multidrug resistance induced by SYP-14288, which could be a concern in increasing the spectrum of resistance in R. solani to commonly used fungicides. And N,2-Dihydroxybenzamide (cas: 89-73-6) was used in the research process.
N,2-Dihydroxybenzamide(cas: 89-73-6) can be used:To prepare phenylboronic acid-based bioconjugates for chromatographic applications;As a ligand to synthesize Fe(III), Cu(II), Ni(II) and Zn(II) complexes.Application In Synthesis of N,2-Dihydroxybenzamide
Reference:
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