Quality Control of 6-Aminonicotinamide《SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells》 was published in 2021. The authors were Mason, Joshua A.;Cockfield, Jordan A.;Pape, Daniel J.;Meissner, Hannah;Sokolowski, Michael T.;White, Taylor C.;Valentin Lopez, Jose C.;Liu, Juan;Liu, Xiaojing;Martinez-Reyes, Inmaculada;Chandel, Navdeep S.;Locasale, Jason W.;Schafer, Zachary T., and the article was included in《Cell Reports》. The author mentioned the following in the article:
Loss of integrin-mediated attachment to extracellular matrix (ECM) proteins can trigger a variety of cellular changes that affect cell viability. Foremost among these is the activation of anoikis, caspase-mediated cell death induced by ECM detachment. In addition, loss of ECM attachment causes profound alterations in cellular metabolism, which can lead to anoikis-independent cell death. Here, we describe a surprising role for serum and glucocorticoid kinase-1 (SGK1) in the promotion of energy production when cells are detached. Our data demonstrate that SGK1 activation is necessary and sufficient for ATP generation during ECM detachment and anchorage-independent growth. More specifically, SGK1 promotes a substantial elevation in glucose uptake because of elevated GLUT1 transcription. In addition, carbon flux into the pentose phosphate pathway (PPP) is necessary to accommodate elevated glucose uptake and PPP-mediated glyceraldehyde-3-phosphate (G3P) is necessary for ATP production Thus, our data show SGK1 as master regulator of glucose metabolism and cell survival during ECM-detached conditions. To complete the study, the researchers used 6-Aminonicotinamide (cas: 329-89-5) .
6-Aminonicotinamide (cas:329-89-5)Quality Control of 6-Aminonicotinamide is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics