Related Products of 2444-46-4In 2022, Zhang, Hongliang;Wang, Weijin;Wang, Bingding;Tan, Hui;Jiao, Ning;Song, Song published 《Electrophilic amidomethylation of arenes with DMSO/MeCN reagents》. 《Organic Chemistry Frontiers》published the findings. The article contains the following contents:
An efficient electrophilic amidomethylation of aromatics was described to construct N-benzylic amides, which are core structures in drugs and natural products. The simple combination of DMSO (DMSO, as the CH2 unit) and acetonitrile (MeCN, as the nitrogen unit) as a highly active amidomethylation reagent enables the efficient C-C, C-N and C=O bond construction. Notably, this method provides a practical protocol for the efficient preparation of deuterated benzylamine derivatives with easily available d6-DMSO or d3-MeCN, and is also applied in the concise synthesis of Nonivamide and Pimavanserin. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .
N-Vanillylnonanamide(cas:2444-46-4) is a capsaicin analog that has been used to study the effects of capsaicin on energy metabolism and bowel disease.Related Products of 2444-46-4 It has been shown to be effective in the treatment of bowel disease, by inhibiting the production of proinflammatory cytokines and prostaglandins.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics