Mazorra Morales, Luis Miguel;Cosme Silva, Glaucia Michelle;Santana, Diederson Bortolini;Pireda, Saulo F.;Dorighetto Cogo, Antonio Jesus;Heringer, Angelo Schuabb;de Oliveira, Tadeu dos Reis;Reis, Ricardo S.;dos Santos Prado, Luis Alfredo;de Oliveira, Andre Vicente;Silveira, Vanildo;Da Cunha, Maura;Barros, Claudia F.;Facanha, Arnoldo R.;Baldet, Pierre;Bartoli, Carlos G.;da Silva, Marcelo Gomes;Oliveira, Jurandi G. published 《Mitochondrial dysfunction associated with ascorbate synthesis in plants》 in 2022. The article was appeared in 《Plant Physiology and Biochemistry (Issy-les-Moulineaux, France)》. They have made some progress in their research.Product Details of 89-73-6 The article mentions the following:
Mitochondria are the major organelles of energy production; however, active mitochondria can decline their energetic role and show a dysfunctional status. Mitochondrial dysfunction was induced by high non-physiol. level of L-galactone-1,4-lactone (L-GalL), the precursor of ascorbate (AsA), in plant mitochondria. The dysfunction induced by L-GalL was associated with the fault in the mitochondrial electron partition and reactive oxygen species (ROS) over-production Using mitochondria from RNAi-plant lines harbouring silenced L-galactone-1,4-lactone dehydrogenase (L-GalLDH) activity, it was demonstrated that such dysfunction is dependent on this enzyme activity. The capacity of alternative respiration was strongly decreased by L-GalL, probably mediated by redox-inactivation of the alternative oxidase (AOX) enzyme. Although, alternative respiration was shown to be the key factor that helps support AsA synthesis in dysfunctional mitochondria. Experiments with respiratory inhibitors showed that ROS formation and mitochondrial dysfunction were more associated with the decline in the activities of COX (cytochrome oxidase) and particularly AOX than with the lower activities of respiratory complexes I and III. The application of high L-GalL concentrations induced proteomic changes that indicated alterations in proteins related to oxidative stress and energetic status. However, supra-optimal L-GalL concentration was not deleterious for plants. Instead, the L-GalLDH activity could be pos. Indeed, it was found that wild type plants performed better growth than L-GalLDH-RNAi plants in response to high non-physiol. L-GalL concentrations The experimental procedure involved many compounds, such as N,2-Dihydroxybenzamide (cas: 89-73-6) .
N,2-Dihydroxybenzamide(cas: 89-73-6) has also been shown to be active against wild-type strains of Candida glabrata, but not against resistant mutants. Product Details of 89-73-6 This drug may have therapeutic potential for bone cancer and metabolic disorders such as obesity.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics