Product Details of 2444-46-4《Direct arene C-H fluorination with 18F– via organic photoredox catalysis》 was published in 2019. The authors were Chen, Wei;Huang, Zeng;Tay, Nicholas E. S.;Giglio, Benjamin;Wang, Mengzhe;Wang, Hui;Wu, Zhanhong;Nicewicz, David A.;Li, Zibo, and the article was included in《Science (Washington, DC, United States)》. The author mentioned the following in the article:
Positron emission tomog. (PET) is a widely used imaging technique for medical diagnostics and pharmaceutical development. As the name implies, it requires tracers that emit positrons, typically through labeling with fluorine or carbon radioisotopes. W. Chen et al. devised a versatile technique to incorporate radioactive fluoride into aromatic rings. The metal-free photochem. method directly substitutes aryl carbon-hydrogen bonds with [18F]fluoride and so is particularly well suited to late-stage transformation of complex mols. into tracers. Science, this issue p. 1170. To complete the study, the researchers used N-Vanillylnonanamide (cas: 2444-46-4) .
N-Vanillylnonanamide(cas:2444-46-4) is also called pelargonic acid vanillylamide or PAVA.Product Details of 2444-46-4 Similar to capsaicin, nonivamide can activate the TRPV1 receptor, thus, stimulate the firing rate of dopaminergic neurons in the ventral tegmental area of the brain and to increase the expression of the serotonin receptor gene HTR2A.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics