Product Details of 329-89-5In 2013, Sugita, Kazunari;Ikenouchi-Sugita, Atsuko;Nakayama, Yasuko;Yoshioka, Haruna;Nomura, Takashi;Sakabe, Jun-Ichi;Nakahigashi, Kyoko;Kuroda, Etsushi;Uematsu, Satoshi;Nakamura, Jun;Akira, Shizuo;Nakamura, Motonobu;Narumiya, Shuh;Miyachi, Yoshiki;Tokura, Yoshiki;Kabashima, Kenji published 《Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production.》. 《Scientific reports》published the findings. The article contains the following contents:
Pellagra is a photosensitivity syndrome characterized by three “D’s”: diarrhea, dermatitis, and dementia as a result of niacin deficiency. However, the molecular mechanisms of photosensitivity dermatitis, the hallmark abnormality of this syndrome, remain unclear. We prepared niacin deficient mice in order to develop a murine model of pellagra. Niacin deficiency induced photosensitivity and severe diarrhea with weight loss. In addition, niacin deficient mice exhibited elevated expressions of COX-2 and PGE syntheses (Ptges) mRNA. Consistently, photosensitivity was alleviated by a COX inhibitor, deficiency of Ptges, or blockade of EP4 receptor signaling. Moreover, enhanced PGE2 production in niacin deficiency was mediated via ROS production in keratinocytes. In line with the above murine findings, human skin lesions of pellagra patients confirmed the enhanced expression of Ptges. Niacin deficiency-induced photosensitivity was mediated through EP4 signaling in response to increased PGE2 production via induction of ROS formation. And 6-Aminonicotinamide (cas: 329-89-5) was used in the research process.
6-Aminonicotinamide (cas:329-89-5)Product Details of 329-89-5 is an aminopyridine, which is a specific pentose inhibitor and thus inhibits the NADP production.It can be used as a reactant for the synthesis of 6-substituted imidazo[1,2-a]pyridines with potential application as chemotherapeutic drugs.
Reference:
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