Application of cas: 329-89-5 | D'Amato, Anthony R. et al. published an article in 2017

Formula: C6H7N3O《Removal of retained electrospinning solvent prolongs drug release from electrospun PLLA fibers》 was published in 2017. The authors were D’Amato, Anthony R.;Schaub, Nicholas J.;Cardenas, Jesus M.;Fiumara, Andrew S.;Troiano, Paul M.;Fischetti, Andrea;Gilbert, Ryan J., and the article was included in《Polymer》. The author mentioned the following in the article:

A major challenge in developing drug-releasing electrospun nanofibers is obtaining long-term drug release over many weeks with no burst release of drug. Here, we present new methods capable of prolonging the diffusive release of small mol. drugs from electrospun poly-L-lactic acid (PLLA) nanofibers. The methods focus on removal of retained electrospinning solvent through fiber heating, maintaining fibers in a laboratory setting, or a combination of these methods. These post-fabrication methods altered the release characteristics of a model small mol. drug, 6-aminonicotinamide (6AN), from PLLA fibers. Specifically, untreated fibers released 6AN over 9 days, and fibers that underwent a combined treatment of maintenance in a laboratory setting and heating released 6AN over 44 days. The unique and simple method presented here prolongs diffusive release of a small mol. drug from electrospun fibers and has potential to assist in lengthening small mol. drug release from a variety of polymeric nanomaterials. The experimental procedure involved many compounds, such as 6-Aminonicotinamide (cas: 329-89-5) .

6-Aminonicotinamide (cas:329-89-5)Formula: C6H7N3O is an inhibitor of the NADP+-dependent enzyme, PGD (6-phosphogluconate dehydrogenase). Studies have also shown that 6-aminonicotinamide induces apoptosis in tumor cells and causes glial cell degeneration.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics