Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 79247-77-1, is researched, SMILESS is NC1=NC(C)=C(Br)S1.[H]Br, Molecular C4H6Br2N2SJournal, Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) called An infrared study of rotational isomerism in thiazole-2-carboxylates, Author is Kaye, Perry T.; Meakins, G. Denis; Willbe, Charles; Williams, Peter R., the main research direction is thiazolecarboxylate IR rotational isomerism; Hantzsch thiourea bromoacetone; bromomethylthiazolecarboxylate ethyl methyl; methylthiazolecarboxylate bromo ethyl methyl; carboxylate thiazole IR rotational isomerism.HPLC of Formula: 79247-77-1.
Twenty-five alkyl thiazole-2-carboxylates with a range of 4- and 5-substituents were prepared through the Hantzsch synthesis. E.g., cyclocondensation reaction of (H2N)2CS with MeCOCH2Br followed by bromination, oxidation, and alkylation gave the thiazole esters I (R = Me, Et). Solutions of these esters show well resolved doublets in the carbonyl IR spectra, due to rotational isomers. The higher wave number components were assigned to the more polar carbonyl O,S-anti-s-trans rotamers and those at lower wave number to the O,S-syn-s-trans forms. Small, but systematic, differences between the Me esters were noted.
Different reactions of this compound(5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide)HPLC of Formula: 79247-77-1 require different conditions, so the reaction conditions are very important.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics