The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide(SMILESS: NC1=NC(C)=C(Br)S1.[H]Br,cas:79247-77-1) is researched.Quality Control of 5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide. The article 《An infrared study of rotational isomerism in thiazole-2-carboxylates》 in relation to this compound, is published in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999). Let’s take a look at the latest research on this compound (cas:79247-77-1).
Twenty-five alkyl thiazole-2-carboxylates with a range of 4- and 5-substituents were prepared through the Hantzsch synthesis. E.g., cyclocondensation reaction of (H2N)2CS with MeCOCH2Br followed by bromination, oxidation, and alkylation gave the thiazole esters I (R = Me, Et). Solutions of these esters show well resolved doublets in the carbonyl IR spectra, due to rotational isomers. The higher wave number components were assigned to the more polar carbonyl O,S-anti-s-trans rotamers and those at lower wave number to the O,S-syn-s-trans forms. Small, but systematic, differences between the Me esters were noted.
After consulting a lot of data, we found that this compound(79247-77-1)Recommanded Product: 5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics