So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).Computed Properties of C5H7ClN2.They published the article 《Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity》 about this compound( cas:84547-64-8 ) in Chungnam Kwahak Yonguchi. Keywords: antiulcer agent omeprazole analog preparation. We’ll tell you more about this compound (cas:84547-64-8).
For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.
Although many compounds look similar to this compound(84547-64-8)Computed Properties of C5H7ClN2, numerous studies have shown that this compound(SMILES:CN1N=C(CCl)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics