Introduction of a new synthetic route about 79247-77-1

This literature about this compound(79247-77-1)Product Details of 79247-77-1has given us a lot of inspiration, and I hope that the research on this compound(5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide) can be further advanced. Maybe we can get more compounds in a similar way.

Kaye, Perry T.; Meakins, G. Denis; Willbe, Charles; Williams, Peter R. published an article about the compound: 5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide( cas:79247-77-1,SMILESS:NC1=NC(C)=C(Br)S1.[H]Br ).Product Details of 79247-77-1. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:79247-77-1) through the article.

Twenty-five alkyl thiazole-2-carboxylates with a range of 4- and 5-substituents were prepared through the Hantzsch synthesis. E.g., cyclocondensation reaction of (H2N)2CS with MeCOCH2Br followed by bromination, oxidation, and alkylation gave the thiazole esters I (R = Me, Et). Solutions of these esters show well resolved doublets in the carbonyl IR spectra, due to rotational isomers. The higher wave number components were assigned to the more polar carbonyl O,S-anti-s-trans rotamers and those at lower wave number to the O,S-syn-s-trans forms. Small, but systematic, differences between the Me esters were noted.

This literature about this compound(79247-77-1)Product Details of 79247-77-1has given us a lot of inspiration, and I hope that the research on this compound(5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics