So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kaye, Perry T.; Meakins, G. Denis; Willbe, Charles; Williams, Peter R. researched the compound: 5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide( cas:79247-77-1 ).Safety of 5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide.They published the article 《An infrared study of rotational isomerism in thiazole-2-carboxylates》 about this compound( cas:79247-77-1 ) in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999). Keywords: thiazolecarboxylate IR rotational isomerism; Hantzsch thiourea bromoacetone; bromomethylthiazolecarboxylate ethyl methyl; methylthiazolecarboxylate bromo ethyl methyl; carboxylate thiazole IR rotational isomerism. We’ll tell you more about this compound (cas:79247-77-1).
Twenty-five alkyl thiazole-2-carboxylates with a range of 4- and 5-substituents were prepared through the Hantzsch synthesis. E.g., cyclocondensation reaction of (H2N)2CS with MeCOCH2Br followed by bromination, oxidation, and alkylation gave the thiazole esters I (R = Me, Et). Solutions of these esters show well resolved doublets in the carbonyl IR spectra, due to rotational isomers. The higher wave number components were assigned to the more polar carbonyl O,S-anti-s-trans rotamers and those at lower wave number to the O,S-syn-s-trans forms. Small, but systematic, differences between the Me esters were noted.
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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics