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This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Formula: C5H7ClN2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8, published in 2016-05-26, which mentions a compound: 84547-64-8, mainly applied to LY3130481 preparation AMPA receptor antagonist TARP gamma8 anticonvulsant epilepsy, Formula: C5H7ClN2.

Transmembrane AMPA receptor regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor trafficking and function. TARP γ-8 is one member of this family and is highly expressed within the hippocampus relative to the cerebellum. A selective TARP γ-8-dependent AMPA receptor antagonist (TDAA) is an innovative approach to modulate AMPA receptors in specific brain regions to potentially increase the therapeutic index relative to known non-TARP-dependent AMPA antagonists. We describe here, for the first time, the discovery of a noncompetitive AMPA receptor antagonist that is dependent on the presence of TARP γ-8. Three major iteration cycles were employed to improve upon potency, CYP1A2-dependent challenges, and in vivo clearance. An optimized mol., compound (-)-25 (LY3130481), was fully protective against pentylenetetrazole-induced convulsions in rats without the motor impairment associated with non-TARP-dependent AMPA receptor antagonists. Compound (-)-25 could be utilized to provide proof of concept for antiepileptic efficacy with reduced motor side effects in patients.

This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Formula: C5H7ClN2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Amide – Wikipedia,
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This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Electric Literature of C5H7ClN2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Electric Literature of C5H7ClN2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about Synthesis of new proton-pump inhibitors. Author is Kim, Hyo-Jeong; Park, Il-Hyun.

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Electric Literature of C5H7ClN2 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

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This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)HPLC of Formula: 84547-64-8 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 84547-64-8, is researched, Molecular C5H7ClN2, about Synthesis of new proton-pump inhibitors, the main research direction is antiulcer agent pyrazole derivative preparation.HPLC of Formula: 84547-64-8.

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)HPLC of Formula: 84547-64-8 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

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This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Category: amides-buliding-blocks was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of new proton-pump inhibitors, published in 1996-06-30, which mentions a compound: 84547-64-8, Name is 3-(Chloromethyl)-1-methyl-1H-pyrazole, Molecular C5H7ClN2, Category: amides-buliding-blocks.

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Category: amides-buliding-blocks was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

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This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Reference of 3-(Chloromethyl)-1-methyl-1H-pyrazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Chungnam Kwahak Yonguchi called Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity, Author is Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun, which mentions a compound: 84547-64-8, SMILESS is CN1N=C(CCl)C=C1, Molecular C5H7ClN2, Reference of 3-(Chloromethyl)-1-methyl-1H-pyrazole.

For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.

This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Reference of 3-(Chloromethyl)-1-methyl-1H-pyrazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Amide – Wikipedia,
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This compound(5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide)HPLC of Formula: 79247-77-1 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

HPLC of Formula: 79247-77-1. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide, is researched, Molecular C4H6Br2N2S, CAS is 79247-77-1, about Synthesis, Properties, and Solar Cell Performance of Poly(4-(p-alkoxystyryl)thiazole)s. Author is Jaeger, Jakob; Schraff, Sandra; Pammer, Frank.

Polythiazoles (PvTzs) featuring conjugated styryl sidechains equipped with different solubilizing p-alkoxy-groups (-OR, R = n-octyl, n-dodecyl, 2-ethylhexyl, 2-hexyldecyl) is prepared by Negishi-coupling polycondensation. Soluble material with number-average mol. weights of up to Mn = 8.5 kDa (polydispersity (PDI) = 1.3, d.p. (DPn) ≈ 20) is obtained, with a head-to-tail content of the PvTzs of ≈77%, as estimated from comparison with reference polymers. The polymers exhibit optical absorption properties similar to their polythiophene analogs, while their electrochem. characterization shows a significant stabilization of their frontier orbital levels. Fluorescence measurements indicate that upon excitation of the electron rich alkoxystyryl side-chains charge transfer onto the more electron deficient polythiazole backbone occurs. This finding is corroborated by d. functional theory (DFT) calculations on oligomeric model systems, which also consistently reproduce the optical properties observed for the polymers. The potential of these materials for applications in organic electronics can be demonstrated by their use as donor materials in organic photovoltaic cells, which exhibit higher open circuit voltages (VOC, up to 0.86 V) than P3HT- or analogous polythiophene-based cells (VOC = 0.5-0.6 V).

This compound(5-Bromo-4-methyl-thiazol-2-ylamine hydrobromide)HPLC of Formula: 79247-77-1 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

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This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)HPLC of Formula: 84547-64-8 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole(SMILESS: CN1N=C(CCl)C=C1,cas:84547-64-8) is researched.Reference of 3-(Chloromethyl)-1-methyl-1H-pyrazole. The article 《1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines》 in relation to this compound, is published in Russian Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:84547-64-8).

Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.

This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)HPLC of Formula: 84547-64-8 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

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Amide – Wikipedia,
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Reference of 3-(Chloromethyl)-1-methyl-1H-pyrazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole, is researched, Molecular C5H7ClN2, CAS is 84547-64-8, about New synthesis and properties of 3-alkyl-, 3-chloroalkyl-, 3-perfluoroalkyl-, and 3-aryl-1-methyl-5-halopyrazoles from chloro(bromo)vinyl ketones and N,N-dimethylhydrazine.

A new regioselective heterocyclization was revealed in the reaction of 2-chloro- and 2,2-dichloro(bromo)vinyl ketones with N,N-dimethylhydrazine to afford 3-substituted 1-methyl-5-halopyrazoles. The reaction is accompanied by elimination of Me halide and formation of up to 90% of N,N,N-trimethylhydrazinium halide as the second product.

This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Reference of 3-(Chloromethyl)-1-methyl-1H-pyrazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

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This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Recommanded Product: 84547-64-8 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Gardinier, Kevin M.; Gernert, Douglas L.; Porter, Warren J.; Reel, Jon K.; Ornstein, Paul L.; Spinazze, Patrick; Stevens, F. Craig; Hahn, Patric; Hollinshead, Sean P.; Mayhugh, Daniel; Schkeryantz, Jeff; Khilevich, Albert; De Frutos, Oscar; Gleason, Scott D.; Kato, Akihiko S.; Luffer-Atlas, Debra; Desai, Prashant V.; Swanson, Steven; Burris, Kevin D.; Ding, Chunjin; Heinz, Beverly A.; Need, Anne B.; Barth, Vanessa N.; Stephenson, Gregory A.; Diseroad, Benjamin A.; Woods, Tim A.; Yu, Hong; Bredt, David; Witkin, Jeffrey M. researched the compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole( cas:84547-64-8 ).Recommanded Product: 84547-64-8.They published the article 《Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8》 about this compound( cas:84547-64-8 ) in Journal of Medicinal Chemistry. Keywords: LY3130481 preparation AMPA receptor antagonist TARP gamma8 anticonvulsant epilepsy. We’ll tell you more about this compound (cas:84547-64-8).

Transmembrane AMPA receptor regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor trafficking and function. TARP γ-8 is one member of this family and is highly expressed within the hippocampus relative to the cerebellum. A selective TARP γ-8-dependent AMPA receptor antagonist (TDAA) is an innovative approach to modulate AMPA receptors in specific brain regions to potentially increase the therapeutic index relative to known non-TARP-dependent AMPA antagonists. We describe here, for the first time, the discovery of a noncompetitive AMPA receptor antagonist that is dependent on the presence of TARP γ-8. Three major iteration cycles were employed to improve upon potency, CYP1A2-dependent challenges, and in vivo clearance. An optimized mol., compound (-)-25 (LY3130481), was fully protective against pentylenetetrazole-induced convulsions in rats without the motor impairment associated with non-TARP-dependent AMPA receptor antagonists. Compound (-)-25 could be utilized to provide proof of concept for antiepileptic efficacy with reduced motor side effects in patients.

This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Recommanded Product: 84547-64-8 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

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This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Recommanded Product: 3-(Chloromethyl)-1-methyl-1H-pyrazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 84547-64-8, is researched, SMILESS is CN1N=C(CCl)C=C1, Molecular C5H7ClN2Journal, Chungnam Kwahak Yonguchi called Synthesis of new proton-pump inhibitors, Author is Kim, Hyo-Jeong; Park, Il-Hyun, the main research direction is antiulcer agent pyrazole derivative preparation.Recommanded Product: 3-(Chloromethyl)-1-methyl-1H-pyrazole.

For development new anti-ulcer agents, we synthesized omeprazole analogs, in which pyridine group was replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and also synthesize substituted benzimidazole rings.

This compound(3-(Chloromethyl)-1-methyl-1H-pyrazole)Recommanded Product: 3-(Chloromethyl)-1-methyl-1H-pyrazole was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics