The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis of new proton-pump inhibitors (2) and tests for it’s biological activity》. Authors are Kim, Hyo-Jeong; Kwon, Tae-Ik; Park, Il-Hyun.The article about the compound:3-(Chloromethyl)-1-methyl-1H-pyrazolecas:84547-64-8,SMILESS:CN1N=C(CCl)C=C1).Name: 3-(Chloromethyl)-1-methyl-1H-pyrazole. Through the article, more information about this compound (cas:84547-64-8) is conveyed.
For development new anti-ulcer agents, we synthesized proton-pump (H+/K+-ATPase) inhibitors which inhibit gastric acid secretion at the last step in the parietal cell. These are omeprazole analogs, in which pyridine group is replaced by pyrazole moiety, to increase pharmacol. activity and to decrease side effects, and we also synthesized substituted benzimidazole rings. The structure of the compounds was identified with 1H-NMR, M.S. and I.R. The compounds with 5-substituted benzimidazoles showed good activity in the following order MeO > Cl > H, and also, 1-benzyl group of pyrazole substituted compounds has enhanced activity.
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Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics