The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-(Chloromethyl)-1-methyl-1H-pyrazole(SMILESS: CN1N=C(CCl)C=C1,cas:84547-64-8) is researched.Category: amides-buliding-blocks. The article 《1-Alkylpyrazoles and 1-alkyl-5-chloropyrazoles from halovinyl ketones and 1,1-dialkylhydrazines》 in relation to this compound, is published in Russian Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:84547-64-8).
Regioselective heterocyclization of chlorovinyl ketones R1COCH:C(R2)Cl (R1 = Me, R2 = H; R1 = n-Pr, R2 = H, Cl; R1 = CH2Cl, R2 = H) with 1,1-dialkyl-hydrazines NH2N(R3)2 (R3 = Me, n-Bu) to pyrazoles I involved intermediate formation of the corresponding dialkylhydrazones II. The mass spectrum fragmentation pattern of chlorine-containing pyrazoles I (R1 = CH2Cl, R2 = H, R3 = Me; R1 = n-Pr, R2 = Cl, R3 = Me) depended on the position of the halogen atom.
Here is a brief introduction to this compound(84547-64-8)Safety of 3-(Chloromethyl)-1-methyl-1H-pyrazole, if you want to know about other compounds related to this compound(84547-64-8), you can read my other articles.
Reference:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics