Month: January 2022

An article Exploring anticancer activity of structurally modified benzylphenoxyacetamide (BPA); I: Synthesis strategies and computational analyses of substituted BPA variants with high anti-glioblastoma potential WOS:000497701200009 published article about ACTIVATED RECEPTOR-ALPHA; PPAR-ALPHA; FENOFIBRATE; GROWTH; CELL; DRUGS; MELANOMA; METABOLISM; INHIBITION; PREDICTION in [Houser, Lisa; Reiss, Krzysztof; Jursic, Branko S.] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA; [Jursic, Branko S.] Stepharm llc, POB 24220, New Orleans, LA 70184 USA; [Stalinska, Joanna; Rak, Monika; Colley, Susan B.; Reiss, Krzysztof] LSU Hlth Sci Ctr, Dept Med, Stanley S Scott Canc Ctr, Neurol Canc Res, New Orleans, LA 70112 USA; [Stalinska, Joanna; Rak, Monika] Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Cell Biol, Krakow, Poland in 2019.0, Cited 69.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Recommanded Product: 91-00-9

Structural variations of the benzylphenoxyacetamide (BPA) molecular skeleton were explored as a viable starting point for designing new anti-glioblastoma drug candidates. Hand-to-hand computational evaluation, chemical modifications, and cell viability testing were performed to explore the importance of some of the structural properties in order to generate, retain, and improve desired anti-glioblastoma characteristics. It was demonstrated that several structural features are required to retain the anti-glioblastoma activity, including a carbonyl group of the benzophenone moiety, as well as 4′-chloro and 2,2-dimethy substituents. In addition, the structure of the amide moiety can be modified in such a way that desirable anti-glioblastoma and physical properties can be improved. Via these structural modifications, more than 50 compounds were prepared and tested for anti-glioblastoma activity. Four compounds were identified (HR28, HR32, HR37, and HR46) that in addition to HR40 (PP1) from our previous study, have been determined to have desirable physical and biological properties. These include high glioblastoma cytotoxicity at low mu M concentrations, improved water solubility, and the ability to penetrate the blood brain barrier (BBB), which indicate a potential for becoming a new class of anti-glioblastoma drugs.

Recommanded Product: 91-00-9. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Name: Diphenylmethanamine. Recently I am researching about ONE-POT SYNTHESIS; CATALYZED KNOEVENAGEL CONDENSATION; METAL-ORGANIC FRAMEWORK; FACILE SYNTHESIS; CHEMOSELECTIVE REDUCTION; GREEN PROCEDURE; IONIC LIQUID; EFFICIENT; NITRILES; HYDRATION, Saw an article supported by the UGC-New DelhiUniversity Grants Commission, India. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Rupanawar, BD; Veetil, SM; Suryavanshi, G. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine

Hypervalent iodine-mediated oxidative olefination of amines with an active methylene compound provides a rapid gateway towards the formation of electrophilic alkenes under mild reaction conditions in good to excellent yields. This is an efficient protocol for the preparation of substituted electrophilic alkenes.

Name: Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Quality Control of 2-(4-Aminophenyl)ethanol. Utsugi, Y; Kobuchi, H; Kawamura, Y; Atito, ASA; Nagao, M; Isoda, H; Miyamae, Y in [Utsugi, Yuki] Univ Tsukuba, Coll Agrobiol Resources Sci, Tsukuba, Ibaraki 3058572, Japan; [Utsugi, Yuki; Atito, Ahmed Salahelden Aboelhamd; Isoda, Hiroko; Miyamae, Yusaku] Univ Tsukuba, Sch Integrat & Global Majors, Masters Doctoral Program Life Sci Innovat, Tsukuba, Ibaraki 3058572, Japan; [Kobuchi, Hirona; Kawamura, Yukio] Kyoto Womens Univ, Fac Home Econ, Dept Food & Nutr, Kyoto 6058501, Japan; [Nagao, Masaya; Miyamae, Yusaku] Kyoto Univ, Grad Sch Biostudies, Kyoto 6068502, Japan; [Isoda, Hiroko] Univ Tsukuba, Alliance Res Mediterranean & North Africa, Tsukuba, Ibaraki 3058572, Japan; [Isoda, Hiroko; Miyamae, Yusaku] Univ Tsukuba, Fac Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan published Importance of the Proximity and Orientation of Ligand-Linkage to the Design of Cinnamate-GW9662 Hybrid Compounds as Covalent PPAR Agonists in 2019.0, Cited 27.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

Covalent agonists of PPAR cause unique receptor conformational changes and behave as selective PPAR modulators, whereas there are few covalent agonists other than endogenous unsaturated fatty acids metabolites. Previously, we established a cell-based strategy to identify new PPAR ligands and synthesized a new-type of covalent agonist that possesses the hybrid structure of a plant-derived cinnamic acid derivative and GW9662, a covalent antagonist. Herein, we report six analogues that differ in how the two fragments are linked together. Compounds with a simplified linker showed potent agonistic activity with improved EC50 values (less than 5 nM), indicating that close proximity between the two fragments improves binding affinity. When the position of cinnamic acid moiety was placed at 4 carbon of aniline ring, PPAR agonist activity was completely abolished. Docking studies suggested that the activation profile likely depends on interaction with the cavity around helix 3, -sheet, and -loop region in the ligand-binding domain. Furthermore, a cell-based assay revealed that agonist-type compounds activate PPAR transcription in a manner dependent on covalent linkage with the Cys285 residue leading to prolonged transactivation. This activation feature reflects pharmacological benefits of covalent drugs, suggesting that these hybrid compounds may serve as potential leads for a new-class of covalent PPAR ligands.

Quality Control of 2-(4-Aminophenyl)ethanol. Welcome to talk about 104-10-9, If you have any questions, you can contact Utsugi, Y; Kobuchi, H; Kawamura, Y; Atito, ASA; Nagao, M; Isoda, H; Miyamae, Y or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020.0 EUR POLYM J published article about TRANSFER RADICAL POLYMERIZATION; CARBON NANOTUBES; CLICK CHEMISTRY; DISPERSED GRAPHENE; ORGANIC-SYNTHESIS; VISIBLE-LIGHT; SURFACE; NANOCOMPOSITES; NANOPARTICLES; BRUSHES in [Railian, Svitlana; Maes, Lowie; Junkers, Tanja] UHasselt Inst Mat Res, Polymer React Design Grp, Agoralaan, B-3590 Diepenbeek, Belgium; [Haven, Joris J.; Junkers, Tanja] Monash Univ, Sch Chem, 19 Rainforest Walk, Clayton, Vic 3800, Australia; [De Sloovere, Dries; Van Bael, Marlies K.; Hardy, An] UHasselt Inst Mat Res, Inorgan & Phys Chem, Agoralaan, B-3590 Diepenbeek, Belgium; [De Sloovere, Dries; Van Bael, Marlies K.; Hardy, An] Energyville, Thor Pk 8320, B-3600 Genk, Belgium; [De Sloovere, Dries; Adriaensens, Peter; Van Bael, Marlies K.; Hardy, An; Deferme, Wim] IMEC Vzw Div IMOMEC, Wetenschapspk 1, B-3590 Diepenbeek, Belgium; [Trouillet, Vanessa] Karlsruhe Inst Technol KIT, Inst Appl Mat IAM, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany; [Trouillet, Vanessa; Welle, Alexander] Karlsruhe Inst Technol KIT, Karlsruhe Nano Micro Facil KNMF, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany; [Welle, Alexander] Karlsruhe Inst Technol KIT, Inst Funct Interfaces, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany; [Adriaensens, Peter] UHasselt Inst Mat Res, Nucl Magnet Resonance Spect Grp, Agoralaan, B-3590 Diepenbeek, Belgium; [Deferme, Wim] UHasselt Inst Mat Res, Wetenschapspk 1, B-3590 Diepenbeek, Belgium in 2020.0, Cited 84.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9. Recommanded Product: 2-(4-Aminophenyl)ethanol

The preparation of well-dispersed graphene/polymer nanocomposites is challenging due to the poor miscibility of graphene sheets in a polymer matrix. To enhance the interaction between both phases, graphene sheets can be decorated with polymer chains. Herein, different strategies to graft poly(methyl methacrylate) (PMMA) and poly(di(ethylene glycol) ethyl ether acrylate) (PDEGA) chains at various positions on graphene oxide and reduced graphene oxide (GO/rGO) sheets are compared. Chain attachment was achieved by grafting-to and grafting-from methods. Grafting-to was performed by classical copper (I)-catalyzed alkyne azide cycloaddition. Using a grafting-from approach, PMMA and PDEGA brushes were grown from GO and rGO sheets via surface-initiated photo-induced copper-mediated polymerization (SI-photoCMP). SI-photoCMP is a robust and efficient method that allows polymerizations to be carried out under mild conditions and with reduced catalyst concentration. Moreover, the successful implementation of SI-photoCMP in a continuous-flow set-up enables easy upscaling of the system and is, therefore, a more efficient and environmentally friendly process for GO/rGO surface modification. By using the grafting-to approach, the grafting density of PMMA (M-n = 2,600 g/mol) was one chain per 990 carbons of graphene. In contrast, longer PMMA chains (M-n = 40,300 g/mol) and higher grafting density were obtained via the grafting-from method (one PMMA chain per 140 carbons of graphene).

Welcome to talk about 104-10-9, If you have any questions, you can contact Railian, S; Haven, JJ; Maes, L; De Sloovere, D; Trouillet, V; Welle, A; Adriaensens, P; Van Bael, MK; Hardy, A; Deferme, W; Junkers, T or send Email.. Recommanded Product: 2-(4-Aminophenyl)ethanol

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Synthesis of 3-indolylmethyl substituted (pyrazolo/benzo)triazinone derivatives under Pd/Cu-catalysis: Identification of potent inhibitors of chorismate mutase (CM) WOS:000487812000051 published article about 1,2,3-BENZOTRIAZIN-4-ONE DERIVATIVES; NEMATOCIDAL ACTIVITIES; INDOLES; 1-ALKYNES; RV1885C; 2-HETEROARYL; DOCKING; PROTEIN; 2-ARYL in [Reddy, Gangireddy Sujeevan; Snehalatha, Ampalam Venkata; Edwin, Rebecca Kristina; Hossain, Kazi Amirul; Misra, Parimal; Pal, Manojit] Dr Reddys Inst Life Sci, Univ Hyderabad Campus, Hyderabad 500046, India; [Reddy, Gangireddy Sujeevan; Giliyaru, Varadaraj Bhat; Hariharapura, Raghu Chandrashekhar; Shenoy, G. Gautham] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal 576104, Karnataka, India in 2019, Cited 38. Category: amides-buliding-blocks. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

The chorismate mutase (CM) is considered as an attractive target for the identification of potential antitubercular agents due to its absence in animals but not in bacteria. A series of 3-indolylmethyl substituted pyrazolo-triazinone derivatives were designed and docked into CM in silico as potential inhibitors. These compounds were efficiently synthesized using the Pd/Cu-catalyzed coupling-cyclization in a single pot involving the construction of indole ring. The methodology was later extended to the preparation of corresponding benzo analogs of pyrazolotriazinones i.e. 3-indolylmethyl substituted benzotriazinone derivatives. Several of these novel compounds showed significant inhibition of CM when tested in vitro at 30 mu M. The SAR (Structure-Activity-Relationship) studies suggested that benzotriazinone moiety was more favorable over the pyrazolotriazinone ring. The two best active compounds showed IC50 similar to 0.4-0.9 mu M (better than the reference/known compounds used) and no toxicity till 30 mu M in vitro.

Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.. Category: amides-buliding-blocks

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: Benzo[d][1,2,3]triazin-4(3H)-one. I found the field of Chemistry very interesting. Saw the article Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita published in 2020, Reprint Addresses Xu, XY (corresponding author), East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China.. The CAS is 90-16-4. Through research, I have a further understanding and discovery of Benzo[d][1,2,3]triazin-4(3H)-one.

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by H-1 NMR, C-13 NMR, F-19 NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1-3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1-3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1-3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L-1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1-3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: Benzo[d][1,2,3]triazin-4(3H)-one

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: Benzo[d][1,2,3]triazin-4(3H)-one. In 2019 TETRAHEDRON LETT published article about CATALYZED DENITROGENATIVE ANNULATION; TERT-BUTYL NITRITE; NEMATOCIDAL ACTIVITIES; SELECTIVE SYNTHESIS; DERIVATIVES; 1,2,3-BENZOTRIAZINE-4-(3H)-ONES; ACID in [Barak, Dinesh S.; Mukhopadhyay, Sushobhan; Dahatonde, Dipak J.; Batra, Sanjay] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Batra, Sanjay] CSIR HRDC, Postal Staff Coll Area, Sect 19, Ghaziabad 201002, India in 2019, Cited 39. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I-2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization. (C) 2018 Elsevier Ltd. All rights reserved.

Recommanded Product: Benzo[d][1,2,3]triazin-4(3H)-one. Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Authors Shaik, JB; Yeggoni, DP; Kandrakonda, YR; Penumala, M; Zinka, RB; Kotapati, KV; Darla, MM; Ampasala, DR; Subramanyam, R; Amooru, DG in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about HUMAN SERUM-ALBUMIN; MOLECULAR-DYNAMICS SIMULATION; MULTIFUNCTIONAL AGENTS; FLAVONOID DERIVATIVES; COUMARIN DERIVATIVES; BETULINIC ACID; DESIGN; INHIBITORS; DISEASE; SERIES in [Shaik, Jeelan Basha; Kandrakonda, Yelamanda Rao; Penumala, Mohan; Zinka, Raveendra Babu; Amooru, Damu Gangaiah] Yogi Vemana Univ, Dept Chem, Kadapa, Andhra Pradesh, India; [Yeggoni, Daniel Pushparaju; Subramanyam, Rajagopal] Univ Hyderabad, Sch Life Sci, Dept Plant Sci, Hyderabad, India; [Kotapati, Kasi Viswanath; Ampasala, Dinakara Rao] Pondicherry Cent Univ, Ctr Bioinformat, Sch Life Sci, Pondicherry, India; [Darla, Mark Manidhar] Sri Venkateswara Univ, Dept Chem, Tirupati, Andhra Pradesh, India in 2019.0, Cited 56.0. Category: amides-buliding-blocks. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

In a search for novel multifunctional anti-Alzheimer agents, a congeneric set of seventeen flavone-8-acrylamide derivatives (8a-q) were synthesized and evaluated for their cholinesterase inhibitory, antioxidant, neuroprotective and modulation of A beta aggregation activities. The target compounds showed effective and selective inhibitory activity against the AChE over BuChE. In addition, the target compounds also showed moderate antioxidant activity and strong neuroprotective capacities, and accelerated dosage-dependently the A beta aggregation. Also, we presented here a complete study on the interaction of 8a, 8d, 8e, 8h and 8i with AChE. Through fluorescence emission studies, the binding sites number found to be 1, binding constants were calculated as 2.04 x 10(4), 2.22 x 10(4), 1.18 x 10(4), 9.8 x 10(3) and 3.2 x 10(4) M-1 and free energy change as -5.83, -5.91, -5.51, -5.41 and -6.12 kcal M-1 at 25 degrees C which were well agreed with the computational calculations indicating a strong binding affinity of flavones and AChE. Furthermore, the CD studies revealed that the secondary structure of AChE became partly unfolded upon binding with 8a, 8d, 8e, 8h and 8i.

Welcome to talk about 91-00-9, If you have any questions, you can contact Shaik, JB; Yeggoni, DP; Kandrakonda, YR; Penumala, M; Zinka, RB; Kotapati, KV; Darla, MM; Ampasala, DR; Subramanyam, R; Amooru, DG or send Email.. Category: amides-buliding-blocks

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Computed Properties of C8H11NO. In 2019.0 ACS MED CHEM LETT published article about BINDING; MECHANISMS; INSIGHTS; ACID in [Giampietro, Letizia; Florio, Rosalba; Recinella, Lucia; Ammazzalorso, Alessandra; Bruno, Isabella; De Filippis, Barbara; Fantacuzzi, Marialuigia; Ferrante, Claudio; Maccallini, Cristina; Verginelli, Fabio; Brunetti, Luigi; Cama, Alessandro; Amoroso, Rosa] Univ G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy; [Laghezza, Antonio; Tortorella, Paolo; Loiodice, Fulvio] Univ Bari Aldo Moro, Dept Pharm Drug Sci, Via E Orabona 4, I-70126 Bari, Italy; [Cerchia, Carmen; Capone, Fabio; Lavecchia, Antonio] Univ Napoli Federico II, Drug Discovery Lab, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy; [Florio, Rosalba; Verginelli, Fabio; Cama, Alessandro] Univ G dAnnunzio, Ctr Aging Sci & Translat Med CeSI MeT, Via Luigi Polacchi 11, I-66100 Chieti, Italy in 2019.0, Cited 30.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

The development of PPAR alpha/gamma dual or PPAR alpha/gamma/S pan-agonists could represent an efficacious approach for a simultaneous pharmacological intervention on carbohydrate and lipid metabolism. Two series of new phenyldiazenyl fibrate derivatives of GL479, a previously reported PPAR alpha/gamma dual agonist, were synthesized and tested. Compound 12a was identified as a PPAR pan-agonist with moderate and balanced activity on the three PPAR isoforms (alpha, gamma, delta). Moreover, docking experiments showed that 12a adopts a different binding mode in PPARy compared to PPARa or PPARS, providing a structural basis for further structure-guided design of PPAR pan-agonists. The beneficial effects of 12a were evaluated both in vitro, on the expression of PPAR target key metabolic genes, and ex vivo in two rat tissue inflammatory models. The obtained results allow considering this compound as an interesting lead for the development of a new class of PPAR pan-agonists endowed with an activation profile exploitable for therapy of metabolic syndrome.

Welcome to talk about 104-10-9, If you have any questions, you can contact Giampietro, L; Laghezza, A; Cerchia, C; Florio, R; Recinella, L; Capone, F; Ammazzalorso, A; Bruno, I; De Filippis, B; Fantacuzzi, M; Ferrante, C; Maccallini, C; Tortorella, P; Verginelli, F; Brunetti, L; Cama, A; Amoroso, R; Loiodice, F; Lavecchia, A or send Email.. Computed Properties of C8H11NO

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Development of novel benzimidazole-derived neddylation inhibitors for suppressing tumor growth in vitro and in vivo WOS:000604903800017 published article about NEDD8-ACTIVATING ENZYME-INHIBITOR; PROTEIN NEDDYLATION; IDENTIFICATION; PATHWAY; DEGRADATION; DISCOVERY; APOPTOSIS; LIGASES in [Chen, Xin; Mao, Fei; Wei, Jinlian; Xu, Yixiang; Li, Baoli; Zhu, Jin; Li, Jian] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, 130 Mei Long Rd, Shanghai 200237, Peoples R China; [Yang, Xi; Ni, Shuaishuai; Jia, Lijun] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Canc Inst, Shanghai 200032, Peoples R China; [Li, Jian] Dali Univ, Coll Pharm & Chem, 5 Xue Ren Rd, Dali 671000, Yunnan, Peoples R China; [Li, Jian] East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, 130 Mei Long Rd, Shanghai 200237, Peoples R China in 2021.0, Cited 41.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Name: Diphenylmethanamine

Ubiquitin-like protein neddylation is overactivated in various human cancers and correlates with disease progression, and targeting this pathway represents a valuable therapeutic strategy. Our previous work disclosed an antihypertensive agent, candesartan cilexetic (CDC), serves as a novel neddylation inhibitor for suppressing tumor growth by targeting Nedd8-activating enzyme (NAE). In this study, 42 benzimidazole derivatives were designed and synthesized based on lead compound CDC to improve the neddylation inhibition and anticancer efficacy. Optimal benzimidazole-derived 35 displayed superior neddylation inhibition in enzyme assay compared to CDC (IC50 = 5.51 mu M vs 16.43 mu M), along with promising target inhibitory activity and killing selectivity in cancer cell. The results of cellular mechanism research combined with tumor growth suppression in human lung cancer cell A549 in vivo, accompanied with docking model, revealed that 35 has the potential to be developed as a promising neddylation inhibitor for anticancer therapy. (C) 2020 Elsevier Masson SAS. All rights reserved.

Name: Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics