Recently I am researching about APOPTOSIS PROTEINS IAPS; HUMAN SERUM-ALBUMIN; X-LINKED INHIBITOR; STRUCTURAL BASIS; CELL-DEATH; REVERSIBLE LIPIDIZATION; CASPASE INHIBITION; POTENT ANTAGONISTS; TUMOR-REGRESSION; BIR DOMAINS, Saw an article supported by the Adams endowment by the Dean’s Office of the David Geffen School of Medicine at UCLA; Burnham endowment by the Dean’s Office of the David Geffen School of Medicine at UCLA; NIH/NIAIDUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Allergy & Infectious Diseases (NIAID) [5U19AI067769]; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Allergy & Infectious Diseases (NIAID) [U19AI067769] Funding Source: NIH RePORTER. Name: Diphenylmethanamine. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Micewicz, ED; Nguyen, C; Micewicz, A; Waring, AJ; McBrid, WH; Ruchala, P. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine
A small group of lipid-conjugated Smac mimetics was synthesized to probe the influence of the position of lipidation on overall anti-cancer activity. Specifically, new compounds were modified with lipid(s) in position 3 and C-terminus. Previously described position 2 lipidated analog M11 was also synthesized. The resulting mini library of Smacs lipidated in positions 2, 3 and C-terminus was screened extensively in vitro against a total number of 50 diverse cancer cell lines revealing that both the position of lipidation as well as the type of lipid, influence their anti-cancer activity and cancer type specificity. Moreover, when used in combination therapy with inhibitor of menin-MLL1 protein interactions, position 2 modified analog SM2 showed strong synergistic anti-cancer properties. The most promising lipid-conjugated analogs SM2 and SM6, showed favorable pharmacokinetics and in vivo activity while administered subcutaneously in the preclinical mouse model. Collectively, our findings suggest that lipid modification of Smacs may be a viable approach in the development of anti-cancer therapeutic leads.
Name: Diphenylmethanamine. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics