Month: November 2021

An article Dynamic Plasmonic Platform To Investigate the Correlation between Far-Field Optical Response and SERS Signal of Analytes WOS:000460214700124 published article about ENHANCED RAMAN-SPECTROSCOPY; SURFACE FUNCTIONALIZATION; GOLD NANORODS; NANOPARTICLES; POLYMERS; MOLECULE in [Mai Nguyen] Hanoi Univ Sci & Technol, Sch Chem Engn, 1 Dai Co Viet Rd, Hanoi 10000, Vietnam; [Kherbouche, Issam; Mangeney, Claire] Univ Paris 05, Lab Chim & Biochim Pharmacolog & Toxicol, UMR 8601, 45 Rue St Peres, F-75006 Paris, France; [Braik, Macilia; Belkhir, Abderrahmane] Univ Mouloud Mammeri, Lab Phys & Chim Quant, BP 17 RP, Tizi Ouzou 15000, Algeria; [Kherbouche, Issam; Boubekeur-Lecaque, Leila; Aubard, Jean; Felidj, Nordin] Univ Paris Diderot, ITODYS Lab, UMR 7086, 15 Rue Jean Antoine de Baif, F-75013 Paris, France in 2019.0, Cited 31.0. Category: amides-buliding-blocks. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9

The design of surface-enhanced Raman spectroscopy (SERS) platforms based on the coupling between plasmonic nanostructures and stimuli-responsive polymers has attracted considerable interest over the past decades for the detection of a wide range of analytes, including pollutants and biological molecules. However, the SERS intensity of analytes trapped inside smart hybrid nanoplatforms is subject to important fluctuations because of the spatial and spectral variation of the plasmonic near-field enhancement (i.e., its dependence with the distance to the nanoparticle surface and with the localized surface plasmon resonance). Such fluctuations may impair interpretation and quantification in sensing devices. In this paper, we investigate the influence of the plasmonic near-field profile upon the Raman signal intensity of analytes trapped inside thermoresponsive polymer-coated gold nanoarrays. For this, well-defined plasmonic arrays (nanosquares and nanocylinders) were modified by poly(N-isopropylacrylamide) (PNIPAM) brushes using surface-initiated atom-transfer radical polymerization. Molecular probes were trapped inside these Au@PNIPAM nanostructures by simple physisorption or by covalent grafting at the end of PNIPAM brushes, using click chemistry. The SERS spectra of molecular probes were studied along various heating/cooling cycles, demonstrating a strong correlation between SERS intensities and near-field spectral profile of underlying nanoparticles, as confirmed by simulations based on the finite difference time domain method. Thermoresponsive plasmonic devices thus provide an ideal dynamic SERS platform to investigate the influence of the near-field plasmonic profile upon the SERS response of analytes.

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Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: 2-(4-Aminophenyl)ethanol. I found the field of Chemistry very interesting. Saw the article Efficient synthesis of cyclic amidine-based fluorophores via 6 pi-electrocyclic ring closure published in 2020, Reprint Addresses Li, M; Hong, L (corresponding author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China.. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol.

Novel 10 pi-electron cyclic amidines with excellent fluorescence properties were synthesized by a general and efficient 6 pi-electrocyclic ring closure of ketenimine and imine starting from N-sulfonyl triazoles and arylamines. The photophysical properties of cyclic amidine fluorophores have been studied in detail and have shown good properties of a large Stokes shift, pH insensitivity, low cytotoxicity and higher photostability, which have great potential for biological imaging. Furthermore, this novel fluorophore was successfully applied to the localization of the NK-1 receptor in living systems.

Recommanded Product: 2-(4-Aminophenyl)ethanol. Bye, fridends, I hope you can learn more about C8H11NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Chen, XL; Zhou, Z; Li, Z; Xu, XY in TAYLOR & FRANCIS LTD published article about ANTICANCER; DISCOVERY; LARGAZOLE in [Chen, Xiulei; Zhou, Zhen; Li, Zhong; Xu, Xiaoyong] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China; [Li, Zhong; Xu, Xiaoyong] Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai, Peoples R China in 2020, Cited 29. Safety of Benzo[d][1,2,3]triazin-4(3H)-one. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by H-1 NMR, C-13 NMR, F-19 NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1-3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1-3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1-3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L-1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1-3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

Safety of Benzo[d][1,2,3]triazin-4(3H)-one. Welcome to talk about 90-16-4, If you have any questions, you can contact Chen, XL; Zhou, Z; Li, Z; Xu, XY or send Email.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Quality Control of Benzo[d][1,2,3]triazin-4(3H)-one. Recently I am researching about ALLYLIC SUBSTITUTION; FUNCTIONALIZATION; HYDROAMINATION; HETEROCYCLES; 2-PYRIDONES; ALKYLATION; DISCOVERY, Saw an article supported by the Natural Science Foundation of Hebei Province of ChinaNatural Science Foundation of Hebei Province [B2019208137]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Zhang, ZG; Dai, SW; Li, L; Jia, CY; Zhang, Y; Li, H. The CAS is 90-16-4. Through research, I have a further understanding and discovery of Benzo[d][1,2,3]triazin-4(3H)-one

We described a novel scandium-catalyzed selective Michael addition of quinazolinones and vinylazaarenes. The protocol proceeds smoothly to give diverse quinazolinone derivatives in moderate to excellent yields. The high practicality of this protocol was proved by excellent chemo selectivity and broad substrate and functional group compatibility. (C) 2020 Elsevier Ltd. All rights reserved.

Quality Control of Benzo[d][1,2,3]triazin-4(3H)-one. Bye, fridends, I hope you can learn more about C7H5N3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recently I am researching about NEDD8-ACTIVATING ENZYME-INHIBITOR; PROTEIN NEDDYLATION; IDENTIFICATION; PATHWAY; DEGRADATION; DISCOVERY; APOPTOSIS; LIGASES, Saw an article supported by the Chinese Minister of Science and Technology grant [2016YFA0501800]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81872747, 21702061, 81625018, 81820108022]; Innovative Research Team of High-level Local Universities in Shanghai; National Special Fund for State Key Laboratory of Bioreactor Engineering [2060204]; National Key R&D Programof China [2017YFB0202600]; Innovation Program of Shanghai Municipal Education CommissionInnovation Program of Shanghai Municipal Education Commission [2019-01-07-00-10-E00056]; Program of Shanghai Academic/Technology Research Leader [18XD1403800]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Chen, X; Yang, X; Mao, F; Wei, JL; Xu, YX; Li, BL; Zhu, J; Ni, SS; Jia, LJ; Li, J. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine. Computed Properties of C13H13N

Ubiquitin-like protein neddylation is overactivated in various human cancers and correlates with disease progression, and targeting this pathway represents a valuable therapeutic strategy. Our previous work disclosed an antihypertensive agent, candesartan cilexetic (CDC), serves as a novel neddylation inhibitor for suppressing tumor growth by targeting Nedd8-activating enzyme (NAE). In this study, 42 benzimidazole derivatives were designed and synthesized based on lead compound CDC to improve the neddylation inhibition and anticancer efficacy. Optimal benzimidazole-derived 35 displayed superior neddylation inhibition in enzyme assay compared to CDC (IC50 = 5.51 mu M vs 16.43 mu M), along with promising target inhibitory activity and killing selectivity in cancer cell. The results of cellular mechanism research combined with tumor growth suppression in human lung cancer cell A549 in vivo, accompanied with docking model, revealed that 35 has the potential to be developed as a promising neddylation inhibitor for anticancer therapy. (C) 2020 Elsevier Masson SAS. All rights reserved.

Computed Properties of C13H13N. Bye, fridends, I hope you can learn more about C13H13N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Barak, DS; Mukhopadhyay, S; Dahatonde, DJ; Batra, S in [Barak, Dinesh S.; Mukhopadhyay, Sushobhan; Dahatonde, Dipak J.; Batra, Sanjay] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Batra, Sanjay] CSIR HRDC, Postal Staff Coll Area, Sect 19, Ghaziabad 201002, India published NaNO2/I-2 as an alternative reagent for the synthesis of 1,2,3-benzotriazin-4(3H)-ones from 2-aminobenzamides in 2019, Cited 39. Name: Benzo[d][1,2,3]triazin-4(3H)-one. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

An efficient transformation of 2-aminobenzamides to 1,2,3-benzotriazin-4(3H)-ones in the presence of sodium nitrite (NaNO2) and Iodine (I-2) is described. The reaction is proposed to proceed via formation of nitrosyl halide that induces nitrosylation of the amino group of 2-aminobenzamide leading to diazotization followed by intramolecular cyclization. (C) 2018 Elsevier Ltd. All rights reserved.

Name: Benzo[d][1,2,3]triazin-4(3H)-one. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Barak, DS; Mukhopadhyay, S; Dahatonde, DJ; Batra, S or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

El Rayes, SM; Ali, IAI; Fathalla, W; Mahmoud, MAA in [El Rayes, Samir M.; Ali, Ibrahim A. I.; Mahmoud, Mostafa A. A.] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia 41529, Egypt; [Fathalla, Walid] Port Said Univ, Fac Engn, Phys & Math Engn Dept, Port Said 42526, Egypt published Synthesis and Biological Activities of Some New Benzotriazinone Derivatives Based on Molecular Docking; Promising HepG2 Liver Carcinoma Inhibitors in 2020, Cited 24. Category: amides-buliding-blocks. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

In one-pot strategy, diazotization of methyl anthranilate 5 followed by addition of amino acid ester hydrochloride, we have prepared methyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanoates 6a-c. Starting with hydrazides 7a,b, N-alkyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanamides 9-10(a-h) and methyl-2-(2-(4-oxobenzotriazin-3(4H)-yl)alkanamido)alkanoates 11- 12(a-e) were prepared via azide coupling. Hydrazones 13-15 were prepared via condensation of hydrazides 7a,b with 4-methoxybenzaldehyde, 4-dimethylaminobenzaldehyde, and/or arabinose. Molecular docking was done for synthesized compounds using MOE 2008-10 software. The compounds 9a, 12a, 12c, 13a, 13b, and 14b have the most pronounced strong binding affinities toward the target E. coli Fab-H receptor, whereas compounds 3, 11e, 12e, and 13a have the most pronounced strong binding affinities toward the target vitamin D receptor. The in vitro antibacterial activities of the highest binding affinity docked compounds were tested against E. coli, Staphylococcus aureus, and Salmonella spp. Majority of the tested compounds showed effective positive results against E. coli, while they were almost inactive against Staphylococcus aureus and Salmonella spp. The in vitro cytotoxic activities of the highest binding affinity-docked compounds were tested against the human liver carcinoma cell line (HepG2). Some compounds showed potent cytotoxic activity with low IC50 values, especially for 3 (6.525 mu M) and 13a (10.97 mu M) than that for standard drug doxorubicin (2.06 mu M).

Welcome to talk about 90-16-4, If you have any questions, you can contact El Rayes, SM; Ali, IAI; Fathalla, W; Mahmoud, MAA or send Email.. Category: amides-buliding-blocks

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

An article Synthesis and Biological Activities of Some New Benzotriazinone Derivatives Based on Molecular Docking; Promising HepG2 Liver Carcinoma Inhibitors WOS:000523299700057 published article about PHARMACOLOGICAL EVALUATION; LIGANDS; GROWTH in [El Rayes, Samir M.; Ali, Ibrahim A. I.; Mahmoud, Mostafa A. A.] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia 41529, Egypt; [Fathalla, Walid] Port Said Univ, Fac Engn, Phys & Math Engn Dept, Port Said 42526, Egypt in 2020, Cited 24. Name: Benzo[d][1,2,3]triazin-4(3H)-one. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

In one-pot strategy, diazotization of methyl anthranilate 5 followed by addition of amino acid ester hydrochloride, we have prepared methyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanoates 6a-c. Starting with hydrazides 7a,b, N-alkyl-2-(4-oxobenzotriazin-3(4H)-yl)-alkanamides 9-10(a-h) and methyl-2-(2-(4-oxobenzotriazin-3(4H)-yl)alkanamido)alkanoates 11- 12(a-e) were prepared via azide coupling. Hydrazones 13-15 were prepared via condensation of hydrazides 7a,b with 4-methoxybenzaldehyde, 4-dimethylaminobenzaldehyde, and/or arabinose. Molecular docking was done for synthesized compounds using MOE 2008-10 software. The compounds 9a, 12a, 12c, 13a, 13b, and 14b have the most pronounced strong binding affinities toward the target E. coli Fab-H receptor, whereas compounds 3, 11e, 12e, and 13a have the most pronounced strong binding affinities toward the target vitamin D receptor. The in vitro antibacterial activities of the highest binding affinity docked compounds were tested against E. coli, Staphylococcus aureus, and Salmonella spp. Majority of the tested compounds showed effective positive results against E. coli, while they were almost inactive against Staphylococcus aureus and Salmonella spp. The in vitro cytotoxic activities of the highest binding affinity-docked compounds were tested against the human liver carcinoma cell line (HepG2). Some compounds showed potent cytotoxic activity with low IC50 values, especially for 3 (6.525 mu M) and 13a (10.97 mu M) than that for standard drug doxorubicin (2.06 mu M).

Name: Benzo[d][1,2,3]triazin-4(3H)-one. Welcome to talk about 90-16-4, If you have any questions, you can contact El Rayes, SM; Ali, IAI; Fathalla, W; Mahmoud, MAA or send Email.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

In 2020.0 J MED CHEM published article about FATTY LIVER-DISEASE; DIET-INDUCED OBESITY; OXIDATIVE-PHOSPHORYLATION; METABOLIC-INHIBITORS; INSULIN-RESISTANCE; CANCER-CELLS; DINITROPHENOL; PROTON; MECHANISM; BIOENERGETICS in [Hargett, Stefan R.; Hoehn, Kyle L.] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA; [Hargett, Stefan R.; Hoehn, Kyle L.] Univ Virginia, Dept Med, Charlottesville, VA 22908 USA; [Chen, Sing-Young; Beretta, Martina; Alexopoulos, Stephanie J.; Shah, Divya P.; Olzomer, Ellen M.; Hoehn, Kyle L.] Univ New South Wales, Sch Biotechnol & Biomol Sci, Kensington, NSW 2033, Australia; [Salamoun, Joseph M.; Garcia, Christopher J.; Murray, Jacob H.; Santos, Webster L.] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA; [Salamoun, Joseph M.; Garcia, Christopher J.; Murray, Jacob H.; Santos, Webster L.] Virginia Tech, Virginia Tech Ctr Drug Discovery, Blacksburg, VA 24061 USA; [Tucker, Simon P.] Continuum Biosci Pty Ltd, Sydney, NSW 2035, Australia; [Tucker, Simon P.] Continuum Biosci Inc, Boston, MA 02116 USA in 2020.0, Cited 93.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. Name: Diphenylmethanamine

Small molecule mitochondrial uncouplers have recently garnered great interest for their potential in treating nonalcoholic steatohepatitis (NASH). In this study, we report the structure-activity relationship profiling of a 6-amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol core, which utilizes the hydroxy moiety as the proton transporter across the mitochondrial inner membrane. We demonstrate that a wide array of substituents is tolerated with this novel scaffold that increased cellular metabolic rates in vitro using changes in oxygen consumption rate as a readout. In particular, compound SHS4121705 (12i) displayed an EC50 of 4.3 mu M in L6 myoblast cells and excellent oral bioavailability and liver exposure in mice. In the STAM mouse model of NASH, administration of 12i at 25 mg kg(-1) day(-1) lowered liver triglyceride levels and improved liver markers such as alanine aminotransferase, NAFLD activity score, and fibrosis. Importantly, no changes in body temperature or food intake were observed. As potential treatment of NASH, mitochondrial uncouplers show promise for future development.

Welcome to talk about 91-00-9, If you have any questions, you can contact Salamoun, JM; Garcia, CJ; Hargett, SR; Murray, JH; Chen, SY; Beretta, M; Alexopoulos, SJ; Shah, DP; Olzomer, EM; Tucker, SP; Hoehn, KL; Santos, WL or send Email.. Name: Diphenylmethanamine

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. Samuelsen, S; Santilli, C; Ahlquist, MSG; Madsen, R in [Samuelsen, SimoneV.; Santilli, Carola; Madsen, Robert] Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark; [Ahlquist, Marten S. G.] KTH Royal Inst Technol, Dept Theoret Chem & Biol, Sch Engn Sci Chem Biotechnol & Hlth, S-10691 Stockholm, Sweden published Development and mechanistic investigation of the manganese(iii) salen-catalyzed dehydrogenation of alcohols in 2019.0, Cited 64.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The first example of a manganese(III) catalyst for the acceptorless dehydrogenation of alcohols is presented. N,N’-Bis(salicylidene)-1,2-cyclohexanediaminomanganese(III) chloride (2) has been shown to catalyze the direct synthesis of imines from a variety of alcohols and amines with the liberation of hydrogen gas. The mechanism has been investigated experimentally with labelled substrates and theoretically with DFT calculations. The results indicate a metal-ligand bifunctional pathway in which both imine groups in the salen ligand are first reduced to form a manganese(III) amido complex as the catalytically active species. Dehydrogenation of the alcohol then takes place by a stepwise outer-sphere hydrogen transfer generating a manganese(III) salan hydride from which hydrogen gas is released.

Category: amides-buliding-blocks. Welcome to talk about 91-00-9, If you have any questions, you can contact Samuelsen, S; Santilli, C; Ahlquist, MSG; Madsen, R or send Email.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics