Product Details of 91-00-9. Recently I am researching about ALPHA-ALLYLATION; ALLYLIC ALKYLATION; DUAL CATALYSIS; ENANTIOSELECTIVE CONSTRUCTION; QUATERNARY STEREOCENTERS; CYCLIZATION REACTIONS; SYNERGISTIC IRIDIUM; PALLADIUM; ALDEHYDES; KETONES, Saw an article supported by the National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21822103, 21820102003, 21772052, 21772053, 21572074]; Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2017AHB047]; International Joint Research Center for Intelligent Biosensing Technology and Health. Published in NATURE PUBLISHING GROUP in LONDON ,Authors: Zhang, MM; Wang, YN; Wang, BC; Chen, XW; Lu, LQ; Xiao, WJ. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine
Catalytic asymmetric cycloadditions via transition-metal-containing dipolar intermediates are a powerful tool for synthesizing chiral heterocycles. However, within the field of palladium catalysis, compared with the well-developed normal electron-demand cycloadditions with electrophilic dipolarophiles, a general strategy for inverse electron-demand ones with nucleophilic dipolarophiles remains elusive, due to the inherent linear selectivity in the key palladium-catalyzed intermolecular allylations. Herein, based on the switched regioselectivity of iridium-catalyzed allylations, we achieved two asymmetric [4+2] cycloadditions of vinyl aminoalcohols with aldehydes and beta,gamma-unsaturated ketones through synergetic iridium and amine catalysis. The activation of vinyl aminoalcohols by iridium catalysts and carbonyls by amine catalysts provide a foundation for the subsequent asymmetric [4+2] cycloadditions of the resulting iridium-containing 1,4-dipoles and (di)enamine dipolarophiles. The former provides a straightforward route to a diverse set of enantio-enriched hydroquinolines bearing chiral quaternary stereocenters, and the later represent an enantio- and diastereodivergent synthesis of chiral hydroquinolines.
Product Details of 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Zhang, MM; Wang, YN; Wang, BC; Chen, XW; Lu, LQ; Xiao, WJ or concate me.
Reference:
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