Recently I am researching about SIGMA-BOND METATHESIS; CHEMOSELECTIVE HYDROGENATION; SELECTIVE HYDROGENATION; GRIGNARD-REAGENTS; SECONDARY AMIDES; CARBONYL; REDUCTION; NITROARENES; COMPLEXES; CARBENES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21572175, 21871186, 21971168]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [20826041D4117]; Center for Computational Science and Engineering at SUSTech; SUSTech start-up fund [Y01216248]. Application In Synthesis of 2-(4-Aminophenyl)ethanol. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhao, LX; Hu, CY; Cong, XF; Deng, GD; Liu, LL; Luo, MM; Zeng, XM. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol
Transition metal catalysis that utilizes N-hetero-cyclic carbenes as noninnocent ligands in promoting transformations has not been well studied. We report here a cyclic (alkyl)(amino)carbene (CAAC) ligand-promoted nitro deoxyge-native hydroboration with cost-effective chromium catalysis. Using 1 mol % of CAAC-Cr precatalyst, the addition of HB-pin to nitro scaffolds leads to deoxygenation, allowing for the retention of various reducible functionalities and the compatibility of sensitive groups toward hydroboration, thereby providing a mild, chemoselective, and facile strategy to form anilines, as well as heteroaryl and aliphatic amine derivatives, with broad scope and particularly high turnover numbers (up to 1.8 X 10(6)). Mechanistic studies, based on theoretical calculations, indicate that the CAAC ligand plays an important role in promoting polarity reversal of hydride of HBpin; it serves as an H-shuttle to facilitate deoxygenative hydroboration. The preparation of several commercially available pharmaceuticals by means of this strategy highlights its potential application in medicinal chemistry.
Application In Synthesis of 2-(4-Aminophenyl)ethanol. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Zhao, LX; Hu, CY; Cong, XF; Deng, GD; Liu, LL; Luo, MM; Zeng, XM or concate me.
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics