I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article A-ring and E-ring modifications of the cytotoxic alkaloid Luotonin A: Synthesis, computational and biological studies published in 2020.0. Formula: C8H11NO, Reprint Addresses Haider, N (corresponding author), Univ Vienna, Dept Pharmaceut Chem, Althanstr 14, A-1090 Vienna, Austria.. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol
A series of new Luotonin A derivatives with substituents at rings A and E was synthesized, together with some E-ring-unsubstituted derivatives. Subsequently, the compound library was examined in silico for their binding into a previously proposed site in the DNA/topoisomerase I binary complex. Whereas no convincing correlation between docking scores and biological data from in vitro assays could be found, one novel 4,9-diamino Luotonin A derivative had strong antiproliferative activity based on massive G2/M phase arrest. As this biological activity clearly differs from the reference compound Camptothecin, this strongly indicates that at least some Luotonin A derivatives may be potent antiproliferative agents, however with a different mode of action.
About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Ibric, A; Battisti, V; Deckardt, S; Haller, AV; Lee, C; Protsch, C; Langer, T; Heffeter, P; Schueffl, HH; Marian, B; Haider, N or concate me.. Formula: C8H11NO
Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics