Reference of 94838-59-2, These common heterocyclic compound, 94838-59-2, name is tert-Butyl 4-aminophenethylcarbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 15 – Preparation of tert-Butyl (4-(2-chloroacetamido)phenethyl)carbamate. tert-Butyl (4-aminophenethyl)carbamate prepared according to Example 14 (7.50 grams, 31.7 mmol, 1.0 eq) was dissolved in CH2C12 (500 mL) and cooled to 0C in an ice bath. DMAP (6.23 g, 51.0 mmol, 1.6 eq) was added in one go and the mixture was allowed to stand for 10 minutes before a solution of chloroacetyl chloride (3.00 ml, 37.7 mmol, 1.2 eq) in 100 ml CH2C12 was added drop wise over 20 minutes to the stirring mixture. The mixture was then left at 0C for 30 minutes and at room temperature for 3 hours before it was concentrated under reduced pressure. The sticky red residue was dissolved in CH2C12 (250 mL) and washed with 0.5 M aqueous acetic acid (2 x 200 mL), 0.5 M aqueous NaHC03 (1 x 100 mL) and dried on anhydrous K2C03. The solution was filtered through a (4 cm x 5 cm long) silica gel plug using 75% ethyl acetate in heptane to elute. Removal of the volatiles under reduce pressure yielded 7.46 g of the title compound (23.8 mmol, 75%). 1H NMR (300 MHz, DMSO- ) 6 10.21 (s, 1H), 7.49 (d, J= 8.4 Hz, 2H), 7.14 (d, J= 8.4 Hz, 2H), 6.84 (t, J= 5.6 Hz, 1H), 4.23 (s, 2H), 3.18 – 2.99 (m, 2H), 2.74 – 2.56 (m, 2H), 1.36 (s, 9H). 13C NMR (101 MHz, DMSO) delta 164.4, 155.5, 136.5, 134.9, 128.9, 119.4, 77.4, 43.5, 41.5, 34.9, 28.2.
Statistics shows that tert-Butyl 4-aminophenethylcarbamate is playing an increasingly important role. we look forward to future research findings about 94838-59-2.
Reference:
Patent; UNIVERSITETET I OSLO; GOLDING, Louise; RONGVED, Pal; ASTRAND, Ove Alexander H°gmoen; BAYER, Annette; LEIROS, Hanna-Kirsti Schr°der; SAMUELSEN, Ørjan; EDVARDSEN, Kine Susann Waade; WO2015/49546; (2015); A1;,
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