S News Application of 445-28-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 445-28-3, its application will become more common.

Some common heterocyclic compound, 445-28-3, name is 2-Fluorobenzamide, molecular formula is C7H6FNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C7H6FNO

A 2 liter 3-neck round bottom flask was charged with 100 g 2-fluorobenzamide (0.719 mol, 1 eq.). An inert atmosphere was introduced by two vacuum/argon cycles. 863 mL IM Meerwein’s/CH2Cl2 solution (0.863 mol, 1.2 eq.) was then added to the flask via canula under N2 pressure, giving initially a slurry which became a clear solution after ~ 30 minutes. After ~ 4 hours stirring at 23 0C under argon, a slurry was again present. The mixture was stirred for a total of 16 hours at 23 0C under argon, then it was poured quickly into a large flask and the CH2Cl2 removed at the rotovap, giving an off-white solid. This solid was then suspended in 250 rnL EtOAc, heated briefly at reflux (~ 30 seconds), then the resultant slurry was filtered while still warm under N2 on a corase- fritted funnel. After drying on the frit under a vigorous flow of N2 for one hour, 155 g 2- fluorobenzimidate 5 (84%) was obtained as a colorless solid. It was immediately bottled and placed in a desiccator. M.p. 128-1310C; 19F NMR (DMSO) delta: -113.8, -154.2 ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 445-28-3, its application will become more common.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG; WO2008/67218; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics