Synthetic Route of 830-43-3, A common heterocyclic compound, 830-43-3, name is 4-(Trifluoromethyl)benzenesulfonamide, molecular formula is C7H6F3NO2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A 10-mL screw cap glass tube with a PP-cap was charged with a magnetic stirring bar, sulfonamide 1 or 6 (0.25 mmol, 1.0 equiv), glyoxylic acid monohydrate (2; 30.0 mg, 0.33 mmol, 1.3 equiv), phenylboronic acid (3a; 61.0 mg, 0.5 mmol, 2.0 equiv), and nitromethane (1.5 mL, 0.17 M wrt sulfonamide) and firmly closed. The resulting mixture was stirred at 60 C for 12 h. After cooling to r.t., the mixture was diluted with acetone and filtered through a short plug of Celite/silica gel. The plug was rinsed with additional acetone and the filtrate was concentrated under reduced pressure. Purification of the crude residue by flash column chromatography afforded the product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Diehl, Andreas M.; Ouadoudi, Omar; Andreadou, Eleni; Manolikakes, Georg; Synthesis; vol. 50; 19; (2018); p. 3936 – 3946;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics