These common heterocyclic compound, 1314538-55-0, name is Potassium (((tert-butoxycarbonyl)amino)methyl)trifluoroborate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1314538-55-0
[01374] To a 3000-mL 4-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen was placed 5-[4-chloro-5-(difluoromethyl)pyridin-2-yl] -2-(trifluoromethyl)pyrimidine (20 g, 64.59 mmol, 1.00 equiv), ethanol (2000 mL), water (400 mL), potassium tert-butyl N-[(trifluoroA4boranyl)methyl]carbamate (20 g, 84.36 mmol, 1.30 equiv), sodium carbonate (22 g, 207.57 mmol,3.20 equiv) and Pd(PPh3)2C12 (5 g, 7.12 mmol, 0.11 equiv). The reaction mixture was first stirred at room temperature for 30 mm and at 80C overnight and filtered. The filtrate was concentrated under vacuum. The residue was applied onto a silica gel colunm eluted with ethyl acetate/petroleum ether (0:1-1:6) to afford 14 g (54%) of tert-butyl N- [[5-(difluoromethyl)-2-[2-(trifluoromethyl)pyrimidin-5 – yl]pyridin-4-yl]methyl]carbamate as a light yellow solid.
The synthetic route of Potassium (((tert-butoxycarbonyl)amino)methyl)trifluoroborate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; VOLGRAF, Matthew; CHEN, Huifen; KOLESNIKOV, Aleksandr; VILLEMURE, Elisia; VERMA, Vishal; WANG, Lan; SHORE, Daniel; DO, Steven; YUEN, Po-wai; HU, Baihua; WU, Guosheng; LIN, Xingyu; LU, Aijun; (537 pag.)WO2016/128529; (2016); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics