Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42137-88-2, name is N,N-Bis(2-chloroethyl)-4-methylbenzenesulfonamide, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C11H15Cl2NO2S
3.4 g (0.0156 mole) of levorotatory (-)-(4-chlorophenyl)phenylmethylamine(prepared in accordance with Example 1.1 of U.S. Patent No. 5478941 ) and 5.1 g(0.0172 mol) of N,N-bis(2-chloroethyl)-4-methylbenzenesulfonamide (prepared inExample 2.3 of U.S. Patent No. 5478941 ) in 6 ml_ (4.4 g or 0.0343 mol) of ethyldiisopropylamine are mixed in a 25 ml_ round-bottomed flask. The mixture is heated under reflux (127 0C) for 4 hours and then cooled, with stirring, to 86 0C and 13.8 ml_ of methanol are added at once. The mixture is then cooled in an ice bath and still stirred for 1 hour. The precipitate which forms is filtered off, washed with 10 ml_ of methanol and dried under vacuum at 40 0C. The product is recrystallized from a 3:1 (v/v) mixture of methanol and acetone. 6 g of levorotatory(-)-1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]piperazine are obtained.M. P: 171.1 0C. Yield: 87.2%.[alpha]D25: -40.68 (c=1 , toluene)Optical purity: 100%Analysis for C24H25CIN2O2S in %:CaIc: C 65.37, H 5.71 , N 6.35, Cl 8.04, S 7.27Found: C 65.95, H 5.80, N 6.60, Cl 8.12, S 7.33
According to the analysis of related databases, 42137-88-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; RAMAYYA, Vaddadi Pattabhi; WO2009/62036; (2009); A2;,
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