Synthetic Route of 75175-77-8, These common heterocyclic compound, 75175-77-8, name is 3-(4-Fluorophenyl)-N,N-dimethylacrylamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of the appropriate enaminone 2a-i (5 mmol) in glacial acetic acid (15 mL), ethyl acetoacetate (5.5 mmol) and ammonium acetate (40 mmol) were added. The reaction mixture was heated under reflux for 5 h. After cooling and pouring into ice-water, the residue obtained was filtered and washed with petroleum ether then with water and finally crystallized from ethanol [41]. The yields of compounds 3a-i were 80%, 77%, 81%, 84%, 86%, 80%, 785, 76%, 83%, respectively.
The synthetic route of 75175-77-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Eldehna, Wagdy M.; Fares, Mohamed; Abdel-Aziz, Marwa M; Abdel-Aziz, Hatem A; Molecules; vol. 20; 5; (2015); p. 8800 – 8815;,
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