Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24167-56-4, name is 4-Fluoro-N,N-dimethylbenzamide, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 24167-56-4
General procedure: Oxalyl chloride (1.0 equiv) was added dropwise at r.t. (except in synthesis of 4e, where addition was at 0 C) to the corresponding N,N-dialkylbenzamide 1 (1.0 equiv) in anhydrous CH2Cl2 (1.0 mL/mmol 1) under N2 atmosphere. The reaction mixture was heated at 35 C for 5 h. Generally, a white solid was observed after few minutes. When the reaction was finished, anhydrous CH2Cl2 was added (4.0 mL/mmol 1) at 0 C; usually at this temperature the solid dissolved. A solution of trichloroacetamidine 2 (1.0 equiv) in anhydrous CH2Cl2 (1.0 mL/mmol 2) was added dropwise at 0 C. Immediately a white suspension formed, and the reaction mixture was stirred overnight at r.t. Finally, DIPEA (2.2 equiv) was added at 0 C; a pale yellow solution resulted. CH2Cl2 (20 mL) was added and the organic phase was washed with saturated NaCl solution, dried over Na2SO4, and concentrated in vacuo. The resulting crude 1,3-diazabutadiene 4 was obtained in quantitative yield, usually contaminated with small quantities of starting material as an oil that slowly crystallized. The 1,3-diazadienes 4 were purified by flash column chromatography (silica gel, hexanes-EtOAc). After purification, 1,3-diazadienes 4 were obtained as crystals or as oils.
According to the analysis of related databases, 24167-56-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Seballos-Resendiz, Arturo; Lechuga-Eduardo, Harim; Barroso-Flores, Joaquin; Martinez-Otero, Diego; Romero-Ortega, Moises; Synthesis; vol. 48; 14; (2016); p. 2205 – 2212;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics