Application of 40724-47-8, These common heterocyclic compound, 40724-47-8, name is 4-Bromomethylbenzenesulfonamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In this example, Compound 1 of the Scheme 2 is coupled with compound 2 of Scheme 2 at the presence of an activating agent BOP to give product 3 of Scheme 2, which then alkylated with substituted benzyl bromide 4 of Scheme 2 to produce the desired product 6 of Scheme 2 and by product 5 of Scheme 2. Compound 6 of Scheme 2 is purified by a silica gel column and then reacted with TFA to cleave the Boc group. Compound 7 of Scheme 2 is alkylated with benzyl bromide, and the reaction mixture is purified by HPLC to yield final product compound of Formula I, which in the exemplified scheme is a white solid with purity >98percent, overall yield about 32percent.
Statistics shows that 4-Bromomethylbenzenesulfonamide is playing an increasingly important role. we look forward to future research findings about 40724-47-8.
Reference:
Patent; INTRA-CELLULAR THERAPIES, INC.; LI, Peng; PENG, Youyi; TOMESCH, John; WENNOGLE, Lawrence P.; ZHANG, Qiang; (15 pag.)US2018/333403; (2018); A1;,
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