1103234-56-5, name is 2,6-Difluoro-3-(propylsulfonamido)benzoic acid, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2,6-Difluoro-3-(propylsulfonamido)benzoic acid
Example 4Propane-1 -sulfonic acid {3-[5-(4-chloro-phenyl)-1 H-pyrrolo[2,3-b]pyridine-3-carbonyl]- 2,4-difluoro-phenyl}-amide (1 )A suspension of sulfonamide acid (9) (1 .2 eq.) in CH2CI2 was treated at roomtemperature with cat. amount of DMF (0.1 1 eq.). Within 30 min a solution ofoxalylchloride (1 .30 eq.) in CH2CI2 was added and the reaction mixture was stirred for 2 h, whereby the corresponding acid chloride was formed. A suspension of aluminium chloride (AICI3, 4 eq.) in CH2CI2 was treated at 0C with a solution of Cl-phenyl azaindole (8) in CH2CI2. To the reaction mixture was subsequently added at room temperature the freshly prepared (above described) acid chloride. Stirring at room temperature for 3 h, aqueous work-up and crystallization from THF/heptane provided the title compound (1 ) as off-white powder in 85% yield. MS (Turbo Spry): 509 (48%), 507 (M+NH4+, 100%), 492 (40%), 490 (M+H+, 84%).
The synthetic route of 1103234-56-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BRUMSTED, Corey James; MOORLAG, Hendrik; RADINOV, Roumen Nikolaev; REN, Yi; WALDMEIER, Pius; WO2012/10538; (2012); A2;,
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