These common heterocyclic compound, 6274-22-2, name is 4-Amino-N-methylbenzamide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C8H10N2O
Example 27; 4-({4-[(1 ,1 -Dimethylethyl)amino]-1 W-pyrrolo[2,3-d]pyrimidin-2-yl}amino)-lambda/-met hylbenzamide trifluoroacetate; lambda/-(1 J-dimethylethyl)-2-iodo-7-[(4-methylphenyl)sulfonyl]-7/-/-pyrrolo[2,3-c(]pyrimidin- 4-amine (O.betammol) was dissolved in DMF (16ml). Bis(dibenzylideneacetone) palladium (10mol%, Aldrich), 2-dicyclohexylphosphino-2′-(lambda/,lambda/-dimethylamino) biphenyl (15mol%), cesium carbonate (0.3mmol) and 4-amino-lambda/-methylbenzamide (0.15mmol) were combined with an aliquot of this solution (2ml). The reaction was heated at 800C for 2h, allowed to cool, filtered through Celite and concentrated. The reaction was dissolved in methanol (1.5ml), treated with sodium methoxide in methanol (0.5M, 500mul), stirred at 700C for 2h and left to stand at room temperature overnight. The reaction was heated for a further 5h, concentrated and purified using MDAP. The fractions containing product were evaporated to dryness to give title compound (3mg). LC/MS; Rt 2.58min, MH+ 339.
The synthetic route of 4-Amino-N-methylbenzamide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2007/42298; (2007); A1;,
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