Some common heterocyclic compound, 33045-52-2, name is Methyl 2-methoxy-5-sulfamoylbenzoate, molecular formula is C9H11NO5S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H11NO5S
EXAMPLE 23 N-(1-cyclopentyl-2-pyrrolidinyl-methyl)-2-methoxy-5-sulphamoyl-benzamide 23 g of methyl 2-methoxy-5-sulphamoyl benzoate (0.09 mole) is dissolved hot, at about 90 C., in 115 ml of glycol in a 500 ml flask fitted with an agitator and a thermometer. The solution is cooled to 50 C. and the ester re-crystallises. 19 g of 1-cyclopentyl-2-amino-methyl-pyrrolidine is added. The suspension obtained is kept at 50 C. After 30 hours the ester is completely dissolved. The solution continues to be heated until a sample taken is found to be completely soluble in acetic acid. The solution is then cooled and the benzamide crystallises slowly. 150 ml of water is added and the precipitate is drained, washed with water and dried. 23 g (68%) of benzamide is obtained with a melting point of 147-148 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 33045-52-2, its application will become more common.
Reference:
Patent; Societe d’Etudes Scientifiques et Industrielle de l’Ile de France; US4673686; (1987); A;,
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