Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 72505-21-6, name is 4-(Trifluoromethyl)thiobenzamide, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 4-(Trifluoromethyl)thiobenzamide
4- (Trifluoromethyl) thiobenzamide (20.5 g, 0.1 mol) was dissolved in tetrahydrofuran (300 [UN)] at room temperature, and then methyl [2-CHLOROACETOACETATE] (12.2 [UN,] 0.1 mol) was added slowly for about 20 minutes therein while stirring. After completion of addition, the mixture was stirred again at room temperature for 30 minutes, and then the mixture was heated and refluxed at 78 to 80 C for 12 hours. After completion of the reaction, the reaction mixture was cooled to room temperature. Subsequently, 50% aqueous solution of sodium hydroxide [(150 NE)] was added and stirred for 20 minutes. The resultant organic layer was separated by extraction with ethyl acetate, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure to thereby yield 28.8 g of the title compound (yield: 95. 6%). ‘H-NMR (300 MHz, [CDCI3)] : 8.01 (d, 2H, [J =] 8.4 Hz), 7.64 (d, 2H, [J= 8. 3] Hz), 3. 84 [(S, 3H),] 2. [73] (s, [3H).]
According to the analysis of related databases, 72505-21-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KANG, Heonjoong; HAM, Jungyeob; WO2003/106442; (2003); A1;,
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