Electric Literature of 7223-30-5,Some common heterocyclic compound, 7223-30-5, name is 3-Phenylpropiolamide, molecular formula is C9H7NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of alkynes 1 (0.5 mmol), 2 (0.6 mmol), palladium chloride (3.2 mg, 3 mol %), ionic liquid (0.5 mL), HX (0.25 mL) in a test tube (10 mL) equipped with a magnetic stirring bar. The mixture was stirred under the atmosphere of air at room temperature. After the reaction was completed, 10 mL ethyl acetate (3×10 mL) was added into the tube. The combined organic layers were washed with brine to neutral, dried over MgSO4, and concentrated in vacuum. Purification of the residue on a preparative TLC afforded the desired products. Residual ionic liquid obtained after the workup was stirred with diethyl ether (2×10 mL) for 15 min, and the ethereal layer was decanted. The ionic liquid was then directly used for the next runs without further dry and reused for up to five runs.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Phenylpropiolamide, its application will become more common.
Reference:
Article; Li, Jianxiao; Yang, Shaorong; Wu, Wanqing; Qi, Chaorong; Deng, Zhongxian; Jiang, Huanfeng; Tetrahedron; vol. 70; 7; (2014); p. 1516 – 1523;,
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