Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6331-71-1, name is 4-Amino-N,N-dimethylbenzamide, A new synthetic method of this compound is introduced below., Formula: C9H12N2O
To a mixture of B-02b (1.68 g, 10.2 mmol) in 30 mL concentrated hydrochloric acid at -10 0C is added a solution of sodium nitrite (755 mg, 10.9 mmol) in 7 mL water. The reaction mixture is stirred for 1 h at 0 0C and then at -5 0C a solution of tin(II) chloride dehydrate (4.81 g, 21.4 mmol) in 10 mL concentrated HCl is added. The cooling bath is removed and the reaction mixture is stirred for 1 h at RT. The reaction mixture is basified with 8 M aqueous sodium hydroxide and extracted with ethyl acetate. The combined organic phases are dried over MgSO4 and concentrated in vacuo. The residue is taken up in diethyl ether and 2 M HCl in diethyl ether is added until no more precipitate is formed. The precipitate is filtered of and dried in vacuo at 40 0C. Yield: 213 mg.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/112565; (2009); A1;,
Amide – Wikipedia,
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