Electric Literature of 78191-00-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 78191-00-1 as follows.
To the product of step (a) (110 g, 0.46 mol) in 1.0 L OF THF AT-78 C was added 236 mL (0.51 mol) of 2.14 M n-butyllithium in hexanes via a dropping funnel. After 30 minutes, N-methyl-N-methoxy acetamide (71 g, 0.69 mol, available from TCI) was added. After 2 hours, the reaction mixture was quenched with water, diluted with 2.0 L of 1.0 M aqueous phosphate buffer (pH = 7. 0) and extracted once with diethyl ether. The diethyl ether phase was washed once with brine, dried over NA2S04, filtered and concentrated under reduced pressure to give a light orange oil. The oil was dissolved in a –122– minimum volume of ethyl acetate, diluted with hexanes, and to give the title compound as a crystalline solid.
According to the analysis of related databases, 78191-00-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THERAVANCE, INC.; WO2004/89892; (2004); A2;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics