54468-86-9, name is 2-Amino-N,N-dimethylbenzenesulfonamide, belongs to amides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2-Amino-N,N-dimethylbenzenesulfonamide
To a screw cap vial was added 2-amino-(N, N-dimethyl) phenylsulphonamide (34.9mg, 0. [17MMOL),] DPT (40.5mg, 0. [17MMOL)] and [CH2CI2] (3mL). The resultant bright orange solution was stirred at room temperature for 1 hour and forty-five minutes. At this time, DPT was again added (21. Omg, 0. [09MMOL)] and after one hour of stirring, a TLC was taken showing the reaction to be 50% complete. DPT was again added (21. Omg, 0. [09MMOL)] and the reaction was heated to [50C] for one hour. The reaction mixture was put through an SPE tube [(CH2CI2)] to yield the title compound as a yellow oil (34. [1 MG,] 98%).
The synthetic route of 54468-86-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NPS ALLELIX CORP.; WO2004/22534; (2004); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics