Reference of 4141-08-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4141-08-6 name is 2-Amino-N-methylbenzamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 2-amino-N-methylbenzamide 15.00g(0.1mol) and triethylamine 12.10g(0.12mol) in 150 mL dichloromethane was added 12.40g(0.11mol) chloroacetyl chloride in 30mL dichloromethane at room temperature for 0.5 hours. Then the reaction mixture was continued stirring at room temperature for another 2-3 hours and monitored by TLC. After the reaction was over, the mixture was concentrated under reduced pressure, the residual was filtered and washed with 50ml of 10% diluted hydrochloric acid, 50ml of saturated sodium bicarbonate solution, 50ml of water and 50ml of petroleum ether successively, then dried to give 18.90g intermediate 2-(2-chloroacetamido)-N-methylbenzamide as white solid with yield of 83.4%, m.p. 155-157C.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Amino-N-methylbenzamide, and friends who are interested can also refer to it.
Reference:
Patent; Sinochem Corporation; Shenyang Research Institute of Chemical Industry Co., Ltd.; REN, Lanhui; LIU, Changling; WANG, Lizeng; LI, Zhinian; SUN, Xufeng; LAN, Jie; WU, Qiang; CHI, Huiwei; EP2636669; (2013); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics