Application of 683-57-8, The chemical industry reduces the impact on the environment during synthesis 683-57-8, name is 2-Bromoacetamide, I believe this compound will play a more active role in future production and life.
Example 25; 2-[4-({|2-(trifluoroniethyl)phenyl]sulfonyl}amino)piperidin-l-yl]acetamide; [0234] To a suspension of N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide hydrochloride salt, example 3, (74 mg, 0.21 mmol) in acetone was added potassium iodide (catalytic amount) and bromoacetamide (33 mg, 0.23 mmol). The reaction mixture was heated (500C, 16 h) and monitored by LCMS. The solvent was removed in vacuo and water was added. The product was extracted with ethyl acetate and concentrated to dryness. The crude residue was purified by flash chromatography using asolvent system comprised of dichloromethane and 10% methanolic dichloromethane (0 to 80%). The isolated free base was dissolved in ethyl acetate and treated with HCl gas to afford the hydrochloride salt of 2- [4-({[2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-l-yl]acetamide (72 mg, 85%).[0235] MS (ESI+) m/z 366;HPLC purity 100.0%, Rtau 4.6 minutes;HRMS: calculated for C4H18F3N3O3S + H+, 366.10937; found (ESI, [MH-H]+), 366.1075;
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromoacetamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; WYETH; WO2008/61016; (2008); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics