Synthetic Route of 98-18-0, A common heterocyclic compound, 98-18-0, name is 3-Aminobenzenesulfonamide, molecular formula is C6H8N2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of intermediate (1.0 equiv.) in isopropanol, 1M hydrochloric acid (1.2 equiv.) and aniline (1.2 equiv.) were added. The reaction stirred at 90oC overnight in a sealed tube. Filtration and washed the resultant by cooled isopropanol, dried under vacuum. The solid was collected
The synthetic route of 98-18-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Pobsuk, Nattakarn; Paracha, Tamkeen Urooj; Chaichamnong, Nattiya; Salaloy, Nattapas; Suphakun, Praphasri; Hannongbua, Supa; Choowongkomon, Kiattawee; Pekthong, Dumrongsak; Chootip, Krongkarn; Ingkaninan, Kornkanok; Gleeson, M. Paul; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 267 – 270;,
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