Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 50667-69-1, name is 2,2,2-Trifluoro-N-(hydroxymethyl)acetamide, A new synthetic method of this compound is introduced below., Application In Synthesis of 2,2,2-Trifluoro-N-(hydroxymethyl)acetamide
A/-(Hydroxymethyl)trifluoroacetamide (6.6 mmol; 0.946 g) is added to a mixture of 2,6- dichloro-nitrobenzene (0.899 mL; 6.6 mmol) and cone. H2S04 (15 mL) at 75C. The mixture is stirred at 75C overnight, poured into ice water and stirred for 1 h. The precipitate is collected by filtration and dried. Yield 0.32 g (15%). MS [M-H]” = 315, HPLC-method B: Rt = 1.43 min.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; PRIEPKE, Henning; DOODS, Henri; KUELZER, Raimund; PFAU, Roland; STENKAMP, Dirk; PELCMAN, Benjamin; ROENN, Robert; LUBRIKS, Dimitrijs; SUNA, Edgars; WO2012/22792; (2012); A1;,
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