Month: September 2021

Category: amides-buliding-blocks. Lamaa, D; Lin, HP; Bzeih, T; Retailleau, P; Alami, M; Hamze, A in [Lamaa, Diana; Lin, Hsin-Ping; Bzeih, Tourin; Alami, Mouad; Hamze, Abdallah] Univ Paris Saclay, Univ Paris Sud, CNRS, BioCIS,Equipe Labellisee Ligue Canc, F-92290 Chatenay Malabry, France; [Retailleau, Pascal] CNRS, Inst Chim Subst Nat, UPR 2301, F-91198 Gif Sur Yvette, France published TBAB-Catalyzed Csp(3)-N Bond Formation by Coupling Pyridotriazoles with Anilines: A New Route to (2-Pyridyl)alkylamines in 2019.0, Cited 52.0. The Name is 2-(4-Aminophenyl)ethanol. Through research, I have a further understanding and discovery of 104-10-9.

A new metal-free procedure allowing Csp(3)-N bond formation through coupling of pyridotriazoles and weakly nucleophilic anilines has been developed. This sustainable reaction shows high tolerance towards functional groups (ketones, free alcohols) leading to 2-picolylamine derivatives. The key to our success is the use of a catalytic amount of TBAB and water as a co-solvent leading to the formation of pyridylalkylamine derivatives. As this coupling tolerates the presence of Csp(2)-Br bond on both partners of the reaction, we performed a sequential one-pot reaction between functionalized triazolopyridines and anilines followed by a second coupling with N-tosylhydrazones leading to the formation of Csp(3)-N and Csp(2)-Csp(2) bonds.

Category: amides-buliding-blocks. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Lamaa, D; Lin, HP; Bzeih, T; Retailleau, P; Alami, M; Hamze, A or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Chen, FS; Hu, SS; Li, SP; Tang, G; Zhao, YF in [Tang, Guo] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China; Xiamen Univ, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China published Visible-light-induced denitrogenative phosphorylation of benzotriazinones: a metal- and additive-free method for accessing ortho-phosphorylated benzamide derivatives in 2021, Cited 54. Computed Properties of C7H5N3O. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4.

Metal-free, visible-light-induced denitrogenative phosphorylation of 1,2,3-benzotriazinones was achieved. With the use of eosin Y as a photoredox catalyst, N,N-diisopropylethylamine as a base, CH3CN-H2O as a solvent and sunlight or a blue LED as a light source, a variety of aryl-phosphonates, aryl-phosphinates, and aryl-phosphine oxides were efficiently prepared. In addition, B(2)pin(2) instead of P-nucleophiles as a radical acceptor was also demonstrated. The key advantages of this newly developed method are the clean reaction profile, use of a low-cost organic-dye catalyst, energy efficiency, broad substrate scope, good to excellent yields and large-scale synthetic applicability. The gram-scale synthesised compounds could be isolated in pure form just upon extraction, followed by re-crystallisation; no tedious chromatographic purification was required.

About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Chen, FS; Hu, SS; Li, SP; Tang, G; Zhao, YF or concate me.. Computed Properties of C7H5N3O

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Application In Synthesis of Diphenylmethanamine. Authors Liang, XY; Yu, P; Fu, C; Shen, YC in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Liang, Xiayu; Yu, Peng; Fu, Chen; Shen, Yongcun] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 122 Luoshi Rd, Wuhan 430070, Peoples R China in 2021, Cited 31. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

A new strategy for the facile synthesis of hydroxyalkylamides through the ring-opening reaction of lactone with amine promoted by dibutyltin acetate was developed. A series of hydroxyalkylamide compounds were obtained and the method was successfully applied to the synthesis of pharmaceutically active molecules tyrosinase inhibitor V and HDAC inhibitor VI via a three-step synthetic pathway. The broad substrate scope, mild reaction conditions and practical application proved the effectiveness, compatibility and practicality of this method. (C) 2021 Elsevier Ltd. All rights reserved.

Application In Synthesis of Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Liang, XY; Yu, P; Fu, C; Shen, YC or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Category: amides-buliding-blocks. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein published in 2019.0, Reprint Addresses Wang, SM (corresponding author), Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA.; Wang, SM (corresponding author), Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.; Wang, SM (corresponding author), Univ Michigan, Dept Pharmacol, Med Sch, Ann Arbor, MI 48109 USA.; Wang, SM (corresponding author), Univ Michigan, Coll Pharm, Med Chem, 428 Church St, Ann Arbor, MI 48109 USA.. The CAS is 91-00-9. Through research, I have a further understanding and discovery of Diphenylmethanamine.

Signal transducer and activator of transcription 3 (STAT3) is a transcription factor and an attractive therapeutic target for cancer and other human diseases. Despite 20 years of persistent research efforts, targeting STAT3 has been very challenging. We report herein the structure-based discovery of potent small-molecule STAT3 degraders based upon the proteolysis targeting chimera (PROTAC) concept. We first designed SI-109 as a potent, small-molecule inhibitor of the STAT3 SH2 domain. Employing ligands for cereblon/cullin 4A E3 ligase and SI-109, we obtained a series of potent PROTAC STAT3 degraders, exemplified by SD-36. SD-36 induces rapid STAT3 degradation at low nanomolar concentrations in cells and fails to degrade other STAT proteins. SD-36 achieves nanomolar cell growth inhibitory activity in leukemia and lymphoma cell lines with high levels of phosphorylated STAT3. A single dose of SD-36 results in complete STAT3 protein degradation in xenograft tumor tissue and normal mouse tissues. SD-36 achieves complete and long-lasting tumor regression in the Molm-16 xenograft tumor model at well-tolerated dose-schedules. SD-36 is a potent, selective, and efficacious STAT3 degrader.

About Diphenylmethanamine, If you have any questions, you can contact Zhou, HB; Bai, LC; Xu, RQ; Zhao, YJ; Chen, JY; McEachern, D; Chinnaswamy, K; Wen, B; Dai, LP; Kumar, P; Yang, CY; Liu, ZM; Wang, M; Liu, L; Meagher, JL; Yi, H; Sun, DX; Stuckey, JA; Wang, SM or concate me.. Category: amides-buliding-blocks

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

In 2020.0 ORG LETT published article about EFFICIENT; ARYLATION; AMIDES in [Gao, Zhenhua; Li, Junchen; Shi, Enxue] State Key Lab NBC Protect Civilian, Beijing 102205, Peoples R China; [Li, Bowen; Aliyu, Muinat; Li, Tiejun; Dong, Wei; Tang, Wenjun] Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China; [Li, Bowen; Tang, Wenjun] Univ Chinese Acad Sci, Sch Chem & Mat Sci, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China in 2020.0, Cited 34.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9. COA of Formula: C13H13N

A general synthesis of chiral alpha,alpha-diaryl carboxamides is developed by enantioselective cross-coupling between 2-bromo-2-aryl carboxamides and arylboronic acids, leading to a series of chiral alpha,alpha-diaryl carboxamides with various electronic properties and functionalities in moderate to excellent enantioselectivities and yields. The employment of a sterically bulky chiral P,P=O ligand L2 is critical for the reactivity and selectivity. This protocol is applied to an efficient asymmetric synthesis of a key intermediate of dopamine receptor agonist SKF 38393.

About Diphenylmethanamine, If you have any questions, you can contact Li, BW; Aliyu, M; Gao, ZH; Li, TJ; Dong, W; Li, JC; Shi, EX; Tang, WJ or concate me.. COA of Formula: C13H13N

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Recommanded Product: 90-16-4. I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Visible-light-induced denitrogenative phosphorylation of benzotriazinones: a metal- and additive-free method for accessing ortho-phosphorylated benzamide derivatives published in 2021, Reprint Addresses Tang, G (corresponding author), Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Fujian, Peoples R China.. The CAS is 90-16-4. Through research, I have a further understanding and discovery of Benzo[d][1,2,3]triazin-4(3H)-one.

Metal-free, visible-light-induced denitrogenative phosphorylation of 1,2,3-benzotriazinones was achieved. With the use of eosin Y as a photoredox catalyst, N,N-diisopropylethylamine as a base, CH3CN-H2O as a solvent and sunlight or a blue LED as a light source, a variety of aryl-phosphonates, aryl-phosphinates, and aryl-phosphine oxides were efficiently prepared. In addition, B(2)pin(2) instead of P-nucleophiles as a radical acceptor was also demonstrated. The key advantages of this newly developed method are the clean reaction profile, use of a low-cost organic-dye catalyst, energy efficiency, broad substrate scope, good to excellent yields and large-scale synthetic applicability. The gram-scale synthesised compounds could be isolated in pure form just upon extraction, followed by re-crystallisation; no tedious chromatographic purification was required.

Recommanded Product: 90-16-4. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Chen, FS; Hu, SS; Li, SP; Tang, G; Zhao, YF or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics

Recommanded Product: Diphenylmethanamine. In 2020.0 ORG BIOMOL CHEM published article about N-C CLEAVAGE; METAL-FREE TRANSAMIDATION; PRIMARY CARBOXAMIDES; SECONDARY AMIDES; CARBOXYLIC-ACIDS; AMIDATION; ESTERIFICATION; CARBONYLATION; AMINES; ESTERS in [Yang, Dahyeon; Lee, Sunwoo] Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea; [Shin, Taeil; Kim, Hyunwoo] Korea Adv Inst Sci & Technol, Dept Chem, Daejeon 34141, South Korea in 2020.0, Cited 56.0. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9.

The transamidation of tertiary amides was achievedvianickel catalysis in combination with briphos ligands.N-Methyl-N-phenylbenzamide derivatives reacted with primary amines in the presence of NiCl2/briphos L4 to provide the transamidated products in moderate to good yields. Primary aromatic amines delivered higher product yields than aliphatic amines.

Recommanded Product: Diphenylmethanamine. About Diphenylmethanamine, If you have any questions, you can contact Yang, D; Shin, T; Kim, H; Lee, S or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Authors Wang, WQ; Wang, ZQ; Sang, W; Zhang, R; Cheng, H; Chen, C; Peng, DY in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Wang, Wan-Qiang; Zhang, Rui; Cheng, Hua] Hubei Univ Arts & Sci, Dept Chem Engn & Food Sci, 296 Longzhong Rd, Xiangyang 441053, Peoples R China; [Wang, Zhi-Qin; Sang, Wei; Chen, Cheng] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, 122 Luoshi Rd, Wuhan 430070, Peoples R China; [Peng, Da-Yong] Jiangxi Agr Univ, Coll Sci, Nanchang 330045, Jiangxi, Peoples R China in 2021.0, Cited 63.0. Product Details of 91-00-9. The Name is Diphenylmethanamine. Through research, I have a further understanding and discovery of 91-00-9

The metal-catalyzed dehydrogenative coupling of alcohols and amines to access amides has been recognized as an atom-economic and environmental-friendly process. Apart from the formation of the amide products, three other kinds of compounds (esters, imines and amines) may also be produced. Therefore, it is of vital importance to investigate product distribution in this transformation. Herein, N-heterocyclic carbene-based Ru (NHC/Ru) complexes [Ru-1]-[Ru-5] with different ancillary ligands were prepared and characterized. Based on these complexes, we selected condition A (without an added NHC precursor) and condition B (with an added NHC precursor) to comprehensively explore the selectivity and yield of the desired amides. After careful evaluation of various parameters, the Ru loadings, added NHC precursors and the electronic/steric properties of ancillary NHC ligands were found to have considerable influence on this catalytic process. (C) 2020 Elsevier Ltd. All rights reserved.

Product Details of 91-00-9. About Diphenylmethanamine, If you have any questions, you can contact Wang, WQ; Wang, ZQ; Sang, W; Zhang, R; Cheng, H; Chen, C; Peng, DY or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

Formula: C8H11NO. I found the field of Chemistry very interesting. Saw the article Improved synthesis of the bifunctional chelator p-SCN-Bn-HOPO published in 2019.0, Reprint Addresses Bhupathiraju, NVSDK (corresponding author), CUNY Hunter Coll, Dept Chem, New York, NY 10065 USA.. The CAS is 104-10-9. Through research, I have a further understanding and discovery of 2-(4-Aminophenyl)ethanol.

The bifunctional ligand p-SCN-Bn-HOPO, which has four 1,2-hydroxypyridinone groups on a spermine backbone with an isothiocyanate linker, has been shown to be an efficient and stable chelator for Zr(iv) and, more importantly, the radioisotope Zr-89 for use in radiolabeling antibodies for positron emission tomography (PET) imaging. Previous studies of Zr-89-HOPO-trastuzumab in mice showed low background, good tumor to organ contrast, and very low bone uptake which show p-SCN-Bn-HOPO to be an important next-generation bifunctional chelator for radioimmunoPET imaging with Zr-89. However, the reported synthesis of p-SCN-Bn-HOPO involves nine steps and multiple HPLC purifications with an overall yield of about 1.4%. Herein we report an improved and efficient synthesis of p-SCN-Bn-HOPO in four steps with 14.3% overall yield which will improve its availability for further biological studies and wider application in PET imaging. The new synthetic route also allows variation in linker length and chemistries which may be helpful in modifying in vivo clearance behaviors of future agents.

Formula: C8H11NO. About 2-(4-Aminophenyl)ethanol, If you have any questions, you can contact Bhupathiraju, NVSDK; Younes, A; Cao, MH; Ali, J; Cicek, HT; Tully, KM; Ponnala, S; Babich, JW; Deri, MA; Lewis, JS; Francesconi, LC; Drain, CM or concate me.

Reference:
Amide – Wikipedia,
,Amide – an overview | ScienceDirect Topics

An article Hexokinase II Inhibitory Effect of Secondary Metabolites Derived from a Streptomyces sp. Associated with Mud Dauber Wasp WOS:000538917100001 published article about BACTERIAL SYMBIONTS; GLYCOLYSIS; CANCER; GERMINATION; ANSAMYCIN; PROVIDE in [Zhang, Xiu-Mei; Wang, Mei; Zheng, Dan; Feng, Ming-Kuan] Shandong Drug & Food Vocat Coll, Dept Pharm, Weihai 264210, Peoples R China; [Peng, Ai-Hong; Xie, Wei-Dong] Shandong Univ, Coll Marine Sci, Dept Pharm, Weihai 264209, Peoples R China in 2020, Cited 43. COA of Formula: C7H5N3O. The Name is Benzo[d][1,2,3]triazin-4(3H)-one. Through research, I have a further understanding and discovery of 90-16-4

Insect-microbial symbioses have vast biochemical diversity, which is beneficial to produce bioactive secondary metabolites. In this study, chemical examination of a Streptomyces sp. associated with a mud dauber wasp led to the isolation of fourteen compounds. Their structures were determined by spectroscopic methods and comparison with literature data. Among the isolates, compounds 1,2,3-benzotriazin-4(1H)-one and 4-(2-aminoethyl)phenyl acetate were first reported from this species. Bioactivities of the isolated compounds were assayed for the first time against hexokinase II. 4-(2-Aminoethyl)phenyl acetate, germicidin B, phenylacetic acid, isogermicidin A and germicidin C displayed significant inhibitory activity against hexokinase II, with the IC50 values of 5.11, 7.11, 7.15, 8.45 and 8.78 mu M, respectively.

COA of Formula: C7H5N3O. About Benzo[d][1,2,3]triazin-4(3H)-one, If you have any questions, you can contact Zhang, XM; Peng, AH; Xie, WD; Wang, M; Zheng, D; Feng, MK or concate me.

Reference:
Patent; Guizhou University; Xue Wei; Zhang Juping; Zhang Cheng; Chen Lijuan; Wang Yihui; Li Pu; Li Qin; Ruan Xianghui; Wang Xiaobin; Wu Xiaoqiong; Wang Jun; (24 pag.)CN107602493; (2019); B;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics