Synthetic Route of 53844-02-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 53844-02-3, name is Benzyl (2-bromoethyl)carbamate, This compound has unique chemical properties. The synthetic route is as follows.
Sodium hydride (60%, 120mg, 3.0mmol) was added to a solution of 2-tert-butoxycarbonylamino-3-fluorobenzoic acid methyl ester from Example 20A (750mg, 2.8mmol) in DMF (8.0ml) while cooling in an ice/water bath. The mixture was allowed to warm to room temperature and stirred for 30min. (2-bromoethyl)carbamic acid benzyl ester (360mg, 2.8mmol) and sodium iodide (420mg, 2.8mmol) were added and the mixture was heated at 65C for 18h. The mixture was cooled and evaporated in vacuo. The residue was partitioned between EtOAc and brine and the organic layer was dried and evaporated in vacuo. The residue was purified by flash chromatography on silica (EtOAc:pet. ether 30:70) to give a colourless gum; yield 340mg, 27%.
The chemical industry reduces the impact on the environment during synthesis Benzyl (2-bromoethyl)carbamate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; FERRING B.V.; WO2006/18443; (2006); A1;,
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