In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 683-57-8, name is 2-Bromoacetamide belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C2H4BrNO
(0.86 g, 10 mmol) piperazine was dissolved in THF and (2.76 g, 20 mmol) potassium carbonate was added and mixture was stirred at room temperature for 20 min and then (2.90 g, 21mmol) 2-bromoacetamine was added. The mixture was stirred for 15 h and the completion of the reaction was monitored by TLC analysis and upon the completion, the solid was filtered with sintered glass funnel. The filtrate was evaporated by rotary evaporator and the residue was dried in vacuum desiccator. The best yields of the desired products were obtained when the reaction was carried out in THF at room temperature with a 1:2 mole ratio of the reagents. Formation of HBr is eliminated with subsequent treatment of this salt with saturated aqueous sodium carbonate. The white crystals were obtained. The compound was characterized using different spectroscopic techniques, including IR, NMR and MS, elemental analyses. Reaction scheme is given in Scheme 1. (0005) Yield: 77%, 1.6g. Anal. calcd. for C8H16N4O2, (200.24g/mol): C 47.99%; H 8.05%; N 27.98%. Found: C 47.83%; H 8.14%; N 27.82%. FT-IR (KBr, cm-1): 1675 nu(C=0, amide), 3323, 3213, 3146 nu(N-H). 1H NMR (delta, ppm, CD3OD): 7.33 (NH2, s, 4H), 3.91(s, CH2-N, 4H), 3.50-3.60 (d t, piperazine ring, 8H), 13C NMR (delta, ppm, CDCl3): 167.89 (C=O), 56.79 (CH2-N, 2C), and 49.74 (piperazine ring, 4C). GS MS (E, m/z): [M] +, 200.99.
The synthetic route of 683-57-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kacan, Mesut; Turkyilmaz, Murat; Karabulut, Ferhat; Altun, Ozlen; Baran, Yakup; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 118; (2014); p. 572 – 577;,
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