Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2227-79-4, name is Benzothioamide, A new synthetic method of this compound is introduced below., Recommanded Product: Benzothioamide
The bottle to the three port by adding benzthioamides (20.00 g, 0 . 146 mol), methanol 200 ml, 1,3-dichloroacetone (22.21 g, 0 . 157 mol), heated up to reflow, reflux reaction 3 hours. Lowering the temperature to after the end of the reaction 30 C the following, the reaction solution into 50 ml of water, with 3×50 ml of ethyl acetate extraction, the resulting organic phase with saturated aqueous solution of sodium bicarbonate (50 ml), saturated sodium chloride aqueous solution after washing (50 ml), dried with anhydrous magnesium sulfate, after concentrating under reduced pressure, the residue by column chromatography separation (showering liquid: ethyl acetate: petroleum ether = 1:10) shall be 21.00 g 4 – (chloro methyl) – 2-phenyl-thiazole, decadent oil, yield: 69%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SINOCHEM CORP, Shenyang Research Institute OfChemical Industry Co., Ltd .; YANG, HUIBIN; LI, BIN; SONG, YUQUAN; LIU, HONGYI; WANG, BIN; ZHANG, YU; FENG, CONG; TONG, YICHUN; CHU, YANFENG; CHEN, LIN; YU, HAIBO; (17 pag.)CN103833667; (2016); B;,
Amide – Wikipedia,
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