Application of 16066-84-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16066-84-5, name is tert-Butyl methylcarbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
[00519] Step C: A microwave reaction tube equipped with a stir bar was charged with 6-(((1s,4s)-4-(6-chloro-3-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-1-yl)cyclohexyl)oxy)-2-methylpyridazin-3(2H)-one (0.029 g, 0.066 mmol), tert-butyl methylcarbamate (0.035 g, 0.26 mmol), dioxane (0.5 mL), dicyclohexyl(2′,6′-diisopropoxy-[1,1′-biphenyl]-2-yl)phosphane (0.012 g, 0.026 mmol), sodium t-butoxide (0.013 g, 0.13 mmol) and Pd2dba3 (0.012 g, 0.013 mmol) under a nitrogen atmosphere. The tube was sealed and warmed to 100 C overnight, partitioned between water/EtOAc, extracted with EtOAc, dried over sodium sulfate and concentrated. The crude material was taken forward without further purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl methylcarbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARRAY BIOPHARMA INC.; ALLEN, Shelley; BOYS, Mark Laurence; COOK, Adam; GAUDINO, John; HINKLIN, Ronald Jay; LAIRD, Ellen; MCNULTY, Oren T.; METCALF, Andrew T.; NEWHOUSE, Brad; ROBINSON, John E.; (545 pag.)WO2019/113190; (2019); A1;,
Amide – Wikipedia,
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