Electric Literature of 201162-53-0,Some common heterocyclic compound, 201162-53-0, name is 3-Boc-3,8-Diazabicyclo[3.2.1]octane, molecular formula is C11H20N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3,8-diazabicyclo [3.2.1] octane-3-carboxylic acid tert-butyl ester (320 mg, 1.5 mmol)And bromoethane (817 mg, 7.5 mmol)Was dissolved in acetonitrile (50 mL), potassium carbonate (1.03 mg, 7.5 mmol) was added and reacted at 40 C for 16 hours.The organic phase was combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound which was extracted with ethyl acetate (50 mL) The title compound was obtained as a color oil (350 mg, yield 97%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Boc-3,8-Diazabicyclo[3.2.1]octane, its application will become more common.
Reference:
Patent; Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.; Wu, Yongqian; (45 pag.)CN104910137; (2017); B;,
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