Synthetic Route of 94838-59-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 94838-59-2 as follows.
A mixture of 2-(3-bromopropoxy)tetrahydro-2//-pyran (669mg,3 mmol), tert- butyl 4- aminophenethylcarbamate (709 mg, 3 mmol) and cesium carbonate (2.9 g, 9 mmol) in DMF (20 mL) was stirred at 110 C for 2 h. TLC showed the reaction completed. The reaction mixture was filtered. The filtrate was concentrated and purified by column chromatography to afford the title compound as yellow oil (l80mg, 15.9% yield). NMR (500 MHz, DMSO-r/6) S: 6.94 (d, J= 8.3 Hz, 2H), 6.84 (t, J= 5.4 Hz, 1H), 6.54 (d, J= 8.4 Hz, 2H), 5.42 (t, J= 5.6 Hz, 1H), 4.61 (t, J= 3.4 Hz, 1H), 3.79 (tt, J= 12.6, 4.8 Hz, 2H), 3.49 (dt, J= 9.4, 6.2 Hz, 2H), 3.16 – 3.02 (m, 4H), 2.58 (d, J= 8.0 Hz, 2H), 1.87 – 1.64 (m, 4H), 1.57 – 1.47 (m, 4H), 1.41 (d, J= 15.5 Hz, 9H).
According to the analysis of related databases, 94838-59-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ZHEJIANG VIMGREEN PHARMACEUTICALS, LTD; SUN, Sanxing; ZHAO, Long; HU, Chongbo; CHEN, Zhengshu; YE, Jinqi; (0 pag.)WO2020/2969; (2020); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics