Reference of 53844-02-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53844-02-3, name is Benzyl (2-bromoethyl)carbamate belongs to amides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a solution of benzyl(2-bromoethyl)carbamate 9 (129 mg, 0.5 mmol) and the corresponding Michael acceptor 11 (0.5 mmol) in THF (2.5 mL) at 0 C, was added NaH (60% in mineral oil, 24 mg, 0.6 mmol) portion by portion. The ice bath was removed and the reaction mixture was stirred for 3 h to 3 days (monitored by TLC), was then poured into a saturated NH4Cl solution, and extracted with ethyl acetate (2 25 mL). The organic phase was washed with brine, dried over MgSO4, filtered, and concentrated in vacuo. The crude mixture was purified by flash chromatography (cyclohexane/EtOAc: 20/ 80).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Benzyl (2-bromoethyl)carbamate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Goermen, Meral; Le Goff, Ronan; Lawson, Ata Martin; Daich, Adam; Comesse, Sebastien; Tetrahedron Letters; vol. 54; 17; (2013); p. 2174 – 2176;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics